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  4. SPO11 Antibody, FITC conjugated

SPO11 Antibody, FITC conjugated

  • 中文名稱：
    SPO11兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA897506LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SPO11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPO11
  • 別名：
    Cancer/testis antigen 35 antibody; CT35 antibody; Meiotic recombination protein SPO 11 antibody; Meiotic recombination protein SPO11 antibody; MGC39953 antibody; SPATA43 antibody; Spermatogenesis associated 43 antibody; SPO 11 antibody; SPO11 antibody; SPO11 meiotic protein covalently bound to DSB antibody; SPO11 meiotic protein covalently bound to DSB homolog antibody; SPO11 meiotic protein covalently bound to DSB like antibody; SPO11_HUMAN antibody; TOPVIA antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Meiotic recombination protein SPO11 protein (28-109AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
  • 基因功能參考文獻：
    1. SPO11 gene C631T polymorphism may contribute as a genetic factor susceptible to cause male infertility in Chinese. PMID: 28050928
    2. Data suggest that the combined genotypes of glutathionine S-transferase GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and meiotic recombination protein SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese. PMID: 26663067
    3. Polymorphisms within the SPO11 gene are linked to the susceptibility of azoospermia and oligozoospermia male infertility. PMID: 25005169
    4. SPO11 might has an effect on premorbid functioning, which increase susceptibility for idiopathic male reproduction PMID: 21556891
    5. Mutations in the human SPO11 gene are not common causes of infertility in man PMID: 16169419
    6. Data show that there is no association between SPO11 gene mutation and premature ovarian failure. PMID: 18166824

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TOP6A family
  • 組織特異性：
    Highly expressed in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11250

    OMIM: 605114

    KEGG: hsa:23626

    STRING: 9606.ENSP00000360310

    UniGene: Hs.159737