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  4. SRRM1 Antibody

SRRM1 Antibody

  • 中文名稱：
    SRRM1兔多克隆抗體
  • 貨號：
    CSB-PA022693GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SRRM1
  • 別名：
    Ser/Arg related nuclear matrix protein antibody; Ser/Arg-related nuclear matrix protein antibody; Serine/arginine repetitive matrix protein 1 antibody; SR related nuclear matrix protein of 160 kDa antibody; SR-related nuclear matrix protein of 160 kDa antibody; SRm160 antibody; Srrm1 antibody; SRRM1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SRRM1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
  • 基因功能參考文獻：
    1. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 was determined using reduced dimensionality NMR. PMID: 11991360
    2. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins and plays a role in spliceosome assembly PMID: 12581738
    3. two contiguous sequences that independently target SRm160 to nuclear matrix sites at splicing speckled domains: amino acids 300-350 and 351-688 PMID: 12624182
    4. Data show that SRm160, a splicing coactivator and component of the exon junction complex (EJC) involved in RNA export, has an adenosine triphosphate (ATP)-dependent mobility. PMID: 15024032
    5. found that the majority of proteins identified in SRm160-containing complexes are associated with pre-mRNA processing. Interestingly, SRm160 is also associated with factors involved in chromatin regulation and sister chromatid cohesion PMID: 16159877
    6. SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. PMID: 16354706

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  • 亞細胞定位：
    Nucleus matrix. Nucleus speckle.
  • 蛋白家族：
    Splicing factor SR family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16638

    OMIM: 605975

    KEGG: hsa:10250

    STRING: 9606.ENSP00000326261

    UniGene: Hs.18192