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  4. SRRM4 Antibody, FITC conjugated

SRRM4 Antibody, FITC conjugated

  • 中文名稱：
    SRRM4兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA012292LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SRRM4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SRRM4
  • 別名：
    SRRM4 antibody; KIAA1853 antibody; Serine/arginine repetitive matrix protein 4 antibody; Medulloblastoma antigen MU-MB-2.76 antibody; Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody; Neural-specific SR-related protein of 100 kDa antibody; nSR100 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions.
  • 基因功能參考文獻：
    1. data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
    2. SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. PMID: 27180064
    3. Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. PMID: 27984743
    4. The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
    5. Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. PMID: 25525873
    6. findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NSR100 family
  • 組織特異性：
    Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29389

    OMIM: 613103

    KEGG: hsa:84530

    STRING: 9606.ENSP00000267260

    UniGene: Hs.744964