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  4. STMN3 Antibody

STMN3 Antibody

  • 中文名稱：
    STMN3兔多克隆抗體
  • 貨號：
    CSB-PA022859GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    STMN3
  • 別名：
    AI604839 antibody; R75323 antibody; RP23-83A14.1 antibody; SCG10-like protein antibody; Scgn10 like protein antibody; Sclip antibody; Stathmin like 3 antibody; Stathmin-3 antibody; STMN3 antibody; STMN3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human STMN3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
  • 基因功能參考文獻(xiàn)：
    1. our findings demonstrate that SCLIP plays an important role in glioma pathology, and may represent a novel therapeutic strategy against human glioma. PMID: 25511414
    2. Overexpression of ID1 in two different cell lines induced STMN3 and GSPT1 at the transcriptional level, while depletion of ID1 reduced their expression. PMID: 25028095
    3. We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP PMID: 23543364
    4. Specific serine-proline phosphorylation and glycogen synthase kinase 3beta-directed subcellular targeting of stathmin 3/Sclip in neurons PMID: 22577147
    5. Studies suggest that a STAT3-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology. PMID: 19824884
    6. The substantial expression of SCLIP in most tissues points out a novel function outside the nervous system and raises the possibility that its coexpression with stathmin could provide some degree of functional redundancy. PMID: 12676564

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  • 亞細(xì)胞定位：
    Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Cytoplasm, cytosol.
  • 蛋白家族：
    Stathmin family
  • 組織特異性：
    Neuron specific.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15926

    OMIM: 608362

    KEGG: hsa:50861

    STRING: 9606.ENSP00000359070

    UniGene: Hs.639609