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  4. SYNJ2 Antibody

SYNJ2 Antibody

  • 中文名稱：
    SYNJ2兔多克隆抗體
  • 貨號：
    CSB-PA023017GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    4 antibody; 5-trisphosphate 5-phosphatase 2 antibody; Inositol phosphate 5' phosphatase 2 antibody; INPP 5H antibody; INPP5H antibody; KIAA0348 antibody; MGC44422 antibody; SJ2 antibody; Synaptic inositol 1 4 5 trisphosphate 5 phosphatase 2 antibody; Synaptic inositol-1 antibody; Synaptojanin-2 antibody; Synaptojanin2 antibody; SYNJ 2 antibody; Synj2 antibody; SYNJ2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SYNJ2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
  • 基因功能參考文獻：
    1. Results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. PMID: 26616230
    2. Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. PMID: 25605973
    3. The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP. PMID: 24077433
    4. Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation. PMID: 23076136
    5. SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities. PMID: 22045296
    6. Single nucleotide polymorphisms in SYNJ2 are associated with personality disorders. PMID: 22213687
    7. SYNJ2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    8. Since Syn 2 is a phosphatidylinositol 4,5-biphosphatase involved in cell growth and rearrangement of actin filaments, the increased Syn 2 expression may correlate with the hairy cell leukemia etiology or the characteristic morphologic alterations. PMID: 14562116
    9. contributes to the role of Rac1 in cell invasion and migration by regulating the formation of invadopodia and lamellipodia PMID: 15548694
    10. Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells PMID: 16102578

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  • 亞細胞定位：
    Cytoplasm. Cell membrane. Membrane raft. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Synaptojanin family; Inositol 1,4,5-trisphosphate 5-phosphatase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11504

    OMIM: 609410

    KEGG: hsa:8871

    STRING: 9606.ENSP00000347792

    UniGene: Hs.434494