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  4. SZT2 Antibody, HRP conjugated

SZT2 Antibody, HRP conjugated

  • 中文名稱：
    SZT2兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA735962LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SZT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SZT2
  • 別名：
    Chromosome 1 open reading frame 84 antibody; FLJ34502 antibody; Hypothetical protein LOC23334 antibody; Protein SZT2 antibody; RP11-506B15.1 antibody; Seizure threshold 2 homolog A antibody; Seizure threshold 2 protein homolog antibody; SZT2 antibody; SZT2_HUMAN antibody; SZT2A antibody; Uncharacterized protein KIAA0467 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein SZT2 protein (2396-2517AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.
  • 基因功能參考文獻：
    1. SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment PMID: 28199315
    2. We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures. PMID: 24324832
    3. mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy. PMID: 23932106
  • 相關疾?。?/div>
    Epileptic encephalopathy, early infantile, 18 (EIEE18)
  • 亞細胞定位：
    Lysosome membrane. Peroxisome.
  • 組織特異性：
    Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29040

    OMIM: 615463

    KEGG: hsa:23334

    STRING: 9606.ENSP00000457168

    UniGene: Hs.643560