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TAPBPL Antibody, Biotin conjugated

  • 中文名稱：
    TAPBPL兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA887144LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TAPBPL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAPBPL
  • 別名：
    FLJ10143 antibody; TAP binding protein like antibody; TAP binding protein related antibody; TAP binding protein related protein antibody; TAP-binding protein-like antibody; TAP-binding protein-related protein antibody; Tapasin like antibody; Tapasin R antibody; Tapasin Related Protein antibody; Tapasin-like antibody; TAPASIN-R antibody; Tapasin-related protein antibody; TAPBP L antibody; TAPBP R antibody; TAPBP-R antibody; Tapbpl antibody; TAPBPR antibody; TPSNR_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tapasin-related protein (201-468AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
  • 基因功能參考文獻(xiàn)：
    1. soluble TAPBPR, consisting of the luminal domain alone, added to intact cells, also functions as an effective peptide editor on surface MHC I molecules. PMID: 30213851
    2. this study reports the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog. PMID: 29025991
    3. this study presents the x-ray structure of the TAPBPR-MHC I complex, which delineates the central step of catalysis. PMID: 29025996
    4. The authors identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle that is known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. The results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with p PMID: 28425917
    5. It is now clear there are two MHC class I specific peptide editors, tapasin and TAPBPR, intimately involved in controlling peptide presentation to the immune system. PMID: 26439010
    6. These results support a role of TAPBPR in stabilizing peptide-receptive conformation(s) of MHC-I, permitting peptide editing. PMID: 26869717
    7. TAPBPR is a new player in the MHC class I presentation pathway. (Review) PMID: 25720504
    8. The longer TAPBPR protein interacted with MHC class I but was attenuated in its ability to down-regulate surface expression of MHC class I. PMID: 24444341
    9. the data indicate that TAPBPR and tapasin bind in a similar orientation to the same face of MHC class I. PMID: 24163410
    10. The function of the tapasin-related protein, TAPBPR, was investigated. PMID: 23401559

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30683

    OMIM: 607081

    KEGG: hsa:55080

    STRING: 9606.ENSP00000266556

    UniGene: Hs.504597