TBC1D15 Antibody, FITC conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TBC1D15 Polyclonal antibody
Uniprot No.：

Q8TC07
基因名：

TBC1D15
別名：

DKFZp686M1379 antibody; DKFZp761D0223 antibody; FLJ12085 antibody; FLJ33191 antibody; GAP for RAB7 antibody; GTPase-activating protein RAB7 antibody; RAB7 GAP antibody; Rab7-GAP antibody; TBC1 domain family member 15 antibody; TBC15_HUMAN antibody; Tbc1d15 antibody; Tre 2 budding uninhibited by benzimidazole cell division cycle 16 domain; domain family member 15 antibody; Tre2/Bub2/Cdc16 domain family member 15 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human TBC1 domain family member 15 protein (283-404AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.
基因功能參考文獻(xiàn)：
1. Report provides evidence for a new function of TBC1D15 in the control of GLUT4 vesicles translocation through regulating Rab7 activity. Glucose uptake was greatly reduced when TBC1D15 was knocked out. PMID: 30316925
2. Demonstrate that TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating Rab7 activity at the interface between mitochondria and isolation membranes. PMID: 24569479
3. TBC1D15 is required for the accumulation of RhoA. PMID: 24337944
4. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
6. This paper primarily describes mouse TBC1D15 but also reports the primary structure of human TBC1D15. PMID: 16055087
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亞細(xì)胞定位：

Cytoplasm.
數(shù)據(jù)庫鏈接：

HGNC: 25694

OMIM: 612662

KEGG: hsa:64786

STRING: 9606.ENSP00000448182

UniGene: Hs.284630