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TBC1D7 Antibody, Biotin conjugated

  • 中文名稱：
    TBC1D7兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA873720LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TBC1D7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TBC1D7
  • 別名：
    TBC1D7 antibody; TBC7 antibody; HSPC239 antibody; TBC1 domain family member 7 antibody; Cell migration-inducing protein 23 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TBC1 domain family member 7 protein (1-293AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
  • 相關(guān)疾?。?/div>
    Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH)
  • 亞細(xì)胞定位：
    Cytoplasmic vesicle. Note=Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
  • 組織特異性：
    Highly expressed in heart, and slightly in kidney, liver and placenta.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21066

    OMIM: 248000

    KEGG: hsa:107080638

    STRING: 9606.ENSP00000348813

    UniGene: Hs.484678