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  4. TBCE Antibody

TBCE Antibody

  • 中文名稱：
    TBCE兔多克隆抗體
  • 貨號：
    CSB-PA613603ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA613603ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TBCE Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TBCE
  • 別名：
    HRD antibody; KCS antibody; KCS1 antibody; Pac2 antibody; tbce antibody; TBCE_HUMAN antibody; Tubulin specific chaperone e antibody; Tubulin-folding cofactor E antibody; Tubulin-specific chaperone E antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tubulin-specific chaperone E protein (328-527AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network.
  • 基因功能參考文獻：
    1. TBCE protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. PMID: 28583220
    2. Although loss of function of TBCE has been documented to impact multiple developmental processes, the present findings provide evidence that hypomorphic TBCE mutations primarily drive neurodegeneration PMID: 27666369
    3. Sanjad-Sakati syndrome molecular pathology has been shown to be due to mutations in the TBCE gene on chromosome 1q42-q43. PMID: 26231322
    4. the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated. PMID: 25908846
    5. tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
    6. TBCE has a role in membrane trafficking in the Golgi and late endosomal compartments, tubulin assembly, and the development of the parathyroid PMID: 12389028
    7. Tbce is critical for the maintenance of microtubules in mouse motor axons PMID: 12389029
    8. The tubulin-specific chaperone E (Tbce) mutation described here suggests that alterations in tubulin assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death. PMID: 12446740
    9. Reviews recent findings on the molecular mechanisms of the development of the parathyroid glands, with special emphasis on the possible role of tubulin chaperone E (TBCE), implicated in the hypopathyroidism, retardation and dysmorphism (HRD) syndrome. PMID: 17008776
    10. TBCE, TBCB and alpha-tubulin form a ternary complex after heterodimer dissociation. These complexes might serve to escort alpha-tubulin towards degradation or recycling, depending on the cell requirements. PMID: 17184771
    11. Depletion of Op18 by means of RNA interference increased the susceptibility of tubulin to TBCE or E-like mediated disruption, while overexpressed Op18 exerted a tubulin-protective effect. PMID: 18262179
    12. Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules. PMID: 19168853
    13. TBCE is required for the normal development and function of neuromuscular synapses and that it promotes microtubule formation PMID: 19297412
    14. TBCE may play a role in development of the anterior pituitary, corpus callosum, and white matter in addition to the parathyroid glands. PMID: 19491227

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  • 相關(guān)疾病：
    Hypoparathyroidism-retardation-dysmorphism syndrome (HRDS); Kenny-Caffey syndrome 1 (KCS1); Encephalopathy, progressive, with amyotrophy and optic atrophy (PEAMO)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    TBCE family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11582

    OMIM: 241410

    KEGG: hsa:6905

    STRING: 9606.ENSP00000355560

    UniGene: Hs.744998