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TCERG1 Antibody, HRP conjugated

  • 中文名稱：
    TCERG1兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA023291LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TCERG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TCERG1
  • 別名：
    CA 150 antibody; Co activator of 150 kDa antibody; Coactivator of 150 kDa antibody; MGC133200 antibody; TAF 2S antibody; TAF2S antibody; TATA box binding protein (TBP) associated factor RNA polymerase II S 150kD antibody; TATA box binding protein associated factor 2S antibody; TATA box binding protein associated factor RNA polymerase II S 150kD antibody; TATA box-binding protein-associated factor 2S antibody; TBP-associated factor, RNA polymerase II, 150-kD antibody; TCERG 1 antibody; TCERG1 antibody; TCRG1_HUMAN antibody; Transcription elongation regulator 1 antibody; Transcription factor CA 150 antibody; Transcription factor CA150 antibody; Urn1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription elongation regulator 1 protein (782-896AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
  • 基因功能參考文獻(xiàn)：
    1. TCERG1 affects expression of multiple mRNAs involved in neuron projection development. PMID: 27844289
    2. The QA repeat domain of TCERG1 is required for relocalization of CEBPalpha. PMID: 26264132
    3. TCERG1 binds independently to elongation and splicing complexes, thus performing their coupling by transient interactions rather than by stable association with one or the other complexes. PMID: 26873599
    4. TCERG1 sensitizes a cell to apoptotic agents, thus promoting apoptosis by regulating the alternative splicing of both the Bcl-x and Fas/CD95 genes. PMID: 26462236
    5. This study reveals that TCERG1 regulates HIV-1 transcriptional elongation by increasing the elongation rate of RNAPII and phosphorylation of Ser 2 within the carboxyl-terminal domain. PMID: 24165037
    6. Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. PMID: 23436654
    7. The FF4 and FF5 domains of transcription elongation regulator 1 (TCERG1) target proteins to the periphery of speckles. PMID: 22453921
    8. We propose that TCERG1 modulates the elongation rate of RNAPII to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5' splice site. PMID: 22158966
    9. TCERG1 can inhibit C/EBPalpha activity regardless of the latter's location in the nucleus PMID: 21503969
    10. mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity PMID: 20215116
    11. Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
    12. Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo. PMID: 15456888
    13. CA150 is a co-repressor of C/EBP proteins and provides a possible mechanism for how C/EBPalpha can repress transcription of specific genes PMID: 16644732
    14. Sequences located at both the amino and carboxyl regions of CA150 are required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes. PMID: 16782886
    15. GRIN2A and TCERG1 may show true association with residual age of onset for Huntington's disease in genetic association tests in 443 affected people from a large set of kindreds from Venezuela. PMID: 17018562
    16. The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells PMID: 18187414
    17. Data provide the first crystal structure of an FF domain and insights into the tandem nature of the FF domains and suggest that, in addition to protein binding, FF domains might be involved in DNA binding. PMID: 19660470
    18. Data gave a model for FF domain organization within tandem arrays suggests a general mechanism by which individual FF domains can manoeuvre to achieve optimal recognition of flexible binding partners, such as the intrinsically-disordered phosphoCTD PMID: 19715701

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Detected in brain neurons.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15630

    OMIM: 605409

    KEGG: hsa:10915

    STRING: 9606.ENSP00000296702

    UniGene: Hs.443465