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  4. TCHH Antibody, Biotin conjugated

TCHH Antibody, Biotin conjugated

  • 中文名稱：
    TCHH兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA023309OD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TCHH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TCHH
  • 別名：
    220K trichohyalin granular protein antibody; Hair follicle protein AHF antibody; MGC157889 antibody; MGC157890 antibody; RP11-107M16.3 antibody; TCHH antibody; THH antibody; THL antibody; TRHY_HUMAN antibody; Trichohyalin antibody; Trichohyalin granular protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Trichohyalin protein (1922-1941AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
  • 基因功能參考文獻(xiàn)：
    1. The difference between the twoinduced pluripotent stem cell(IPSC) clones in TCHH methylation did not have an obvious effect on its expression in 3D human epidermal equivalent, suggesting that differentiation and tissue formation may mitigate variations in the iPSC methylome. PMID: 27460132
    2. To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575). PMID: 27487801
    3. Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder. PMID: 20722389
    4. BMP-4 signalling activates AHF transcription in hair follicles. PMID: 18643848
    5. In human keratinocytes, we found BMP-4 facilitates trichohyalin (THH) transcription, and lamin C plays a key role in the posttranslational stabilization of THH. PMID: 18643848
    6. Common variants in the TCHH gene are associated with straight hair in Europeans. PMID: 19896111

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  • 相關(guān)疾?。?/div>
    Uncombable hair syndrome 3 (UHS3)
  • 蛋白家族：
    S100-fused protein family
  • 組織特異性：
    Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11791

    OMIM: 190370

    KEGG: hsa:7062

    STRING: 9606.ENSP00000357794

    UniGene: Hs.432416