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TGFBRAP1 Antibody

  • 中文名稱：
    TGFBRAP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA819888LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA819888LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TGFBRAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TGFBRAP1
  • 別名：
    TGFBRAP1 antibody; Transforming growth factor-beta receptor-associated protein 1 antibody; TGF-beta receptor-associated protein 1 antibody; TRAP-1 antibody; TRAP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transforming growth factor-beta receptor-associated protein 1 protein (401-600AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，TGFBRAP1 Antibody (CSB-PA819888LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TGFBRAP1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA819888LB01HU TGFBRAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA819888LC01HU TGFBRAP1 Antibody, FITC conjugated
    Biotin CSB-PA819888LD01HU TGFBRAP1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.
  • 基因功能參考文獻(xiàn)：
    1. Vps3 and Vps8 are required for recycling of beta1 integrins. PMID: 29476049
    2. MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
    3. the association of rs2679860 polymorphisms of TGFBRAP1 and DBP variation as well as plasma levels of TGF-beta1 PMID: 25856002
    4. In the absence of Langerhans cells (LC), contact hypersensitivity (CHS) reactions in langerin-positive dendritic cell-specific TGF-betaR1-deficient mice are diminished, providing further evidence against a regulatory role for LC in CHS. PMID: 21998450
  • 亞細(xì)胞定位：
    Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
  • 蛋白家族：
    TRAP1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16836

    OMIM: 606237

    KEGG: hsa:9392

    STRING: 9606.ENSP00000258449

    UniGene: Hs.446350