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TM7SF2 Antibody

  • 中文名稱：
    TM7SF2兔多克隆抗體
  • 貨號：
    CSB-PA275949
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA275949(TM7SF2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA275949(TM7SF2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TM7SF2
  • 別名：
    TM7SF2; ANG1; Delta(14-sterol reductase TM7SF2; Delta-14-SR; 3-beta-hydroxysterol Delta; 14-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human TM7SF2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum. PMID: 19940018
    2. Results show that the TM7SF2 gene product SR-1 and six chimeras containing SR-1 and Neurospora erg-3 sequences fail to complement sterol c-14 reductase mutants in Neurospora and yeast. PMID: 11937680
    3. a primary role in human cholesterol biosynthesis PMID: 16784888
  • 亞細(xì)胞定位：
    Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ERG4/ERG24 family
  • 組織特異性：
    Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, testis and adrenal gland, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11863

    OMIM: 603414

    KEGG: hsa:7108

    STRING: 9606.ENSP00000279263

    UniGene: Hs.31130