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  4. TNMD Antibody, HRP conjugated

TNMD Antibody, HRP conjugated

  • 中文名稱：
    TNMD兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA024007LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TNMD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TNMD
  • 別名：
    BRICD4 antibody; BRICHOS domain containing 4 antibody; CHM1 LIKE antibody; ChM1L antibody; Chondromodulin I like antibody; Chondromodulin I like protein antibody; Chondromodulin-1-like protein antibody; Chondromodulin-I-like protein antibody; hChM1L antibody; hTeM antibody; Myodulin antibody; TeM antibody; Tendin antibody; Tenomodulin antibody; Tenomodulin protein antibody; Tnmd antibody; TNMD_HUMAN antibody; UNQ771/PRO1565 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Tenomodulin protein (131-254AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be an angiogenesis inhibitor.
  • 基因功能參考文獻：
    1. our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues. PMID: 28566251
    2. TNMD is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals. TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. PMID: 26880110
    3. results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain PMID: 23593173
    4. Report differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin and suggest possible roles in tenocyte proliferation and tendon injury. PMID: 22700804
    5. According to these results the sequence variation of TNMD is not associated with alzheimer disease, but might modify the effect of APOE epsilon4-allele in women. PMID: 19524323
    6. Polymorphisms are associated with adiposity and also with glucose metabolism and conversion from glucose intolerance to type 2 diabetes. PMID: 17495183
    7. Tenomodulin is expressed abundantly in the elastin-rich subendothelial outer layer of the normal chordae tendineae cordis. PMID: 18838562
    8. TNMD could be a novel candidate gene for age-related macular degeneration. PMID: 19381347
    9. Human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. PMID: 19602561

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  • 亞細胞定位：
    [Isoform 1]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 2]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    Chondromodulin-1 family
  • 組織特異性：
    Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17757

    OMIM: 300459

    KEGG: hsa:64102

    STRING: 9606.ENSP00000362122

    UniGene: Hs.132957