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TNRC6C Antibody, FITC conjugated

  • 中文名稱：
    TNRC6C兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA862070LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TNRC6C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TNRC6C
  • 別名：
    KIAA1582 antibody; TNR6C_HUMAN antibody; TNRC 6C antibody; Tnrc6c antibody; Trinucleotide repeat containing 6C antibody; Trinucleotide repeat containing gene 6C protein antibody; Trinucleotide repeat-containing gene 6C protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Trinucleotide repeat-containing gene 6C protein (157-421AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
  • 基因功能參考文獻(xiàn)：
    1. These findings reveal that despite species-specific differences in the relative strength of the PABPC1-binding sites, the interaction between GW182 proteins and PABPC1 is critical for miRNA-mediated silencing in animal cells. PMID: 21063388
    2. The authors show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. PMID: 20098421
    3. Through deletion and mutagenesis, study identified the C-terminal part of TNRC6C encompassing the RRM RNA-binding motif as a key effector domain mediating protein synthesis repression by TNRC6C. PMID: 19304925
    4. Our findings indicate that TNRC6C, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
  • 蛋白家族：
    GW182 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29318

    OMIM: 610741

    KEGG: hsa:57690

    STRING: 9606.ENSP00000336783

    UniGene: Hs.406810