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  4. TPTE2 Antibody, FITC conjugated

TPTE2 Antibody, FITC conjugated

  • 中文名稱：
    TPTE2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA757850LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TPTE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TPTE2
  • 別名：
    TPTE2; TPIP; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Lipid phosphatase TPIP; TPTE and PTEN homologous inositol lipid phosphatase
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 protein (167-411AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.; Shows no phosphoinositide phosphatase activity.
  • 基因功能參考文獻(xiàn)：
    1. The role of TPTE2 in gallbladder cancer cells PMID: 25676706
    2. TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP and Dr-VSP, have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well. PMID: 22896666
    3. findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex PMID: 22311048
    4. the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells PMID: 22164291
  • 亞細(xì)胞定位：
    [Isoform 3]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 4]: Cytoplasm.
  • 組織特異性：
    Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17299

    OMIM: 606791

    KEGG: hsa:93492

    STRING: 9606.ENSP00000372437

    UniGene: Hs.377488