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TRAF3IP3 Antibody

  • 中文名稱：
    TRAF3IP3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA896865LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Rat heart tissue, Rat liver tissue
      All lanes: TRAF3IP3 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64, 62, 41 kDa
      Observed band size: 64, 62, 41 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA896865LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TRAF3IP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRAF3IP3
  • 別名：
    TRAF3IP3 antibody; T3JAM antibody; TRAF3-interacting JNK-activating modulator antibody; TRAF3-interacting protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TRAF3-interacting JNK-activating modulator protein (74-185AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，TRAF3IP3 Antibody (CSB-PA896865LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TRAF3IP3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA896865LB01HU TRAF3IP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA896865LC01HU TRAF3IP3 Antibody, FITC conjugated
    Biotin CSB-PA896865LD01HU TRAF3IP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1.
  • 基因功能參考文獻(xiàn)：
    1. This paper provides an alignment of the mouse and human proteins. PMID: 14572659
    2. TRAF3IP3 stimulated cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway PMID: 17868742
  • 亞細(xì)胞定位：
    Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane. Mitochondrion outer membrane.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30766

    OMIM: 608255

    KEGG: hsa:80342

    STRING: 9606.ENSP00000355991

    UniGene: Hs.147434