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TUBB2B Antibody

  • 中文名稱：
    TUBB2B兔多克隆抗體
  • 貨號：
    CSB-PA025321GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    TUBB2BTubulin beta-2B chain antibody
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TUBB2B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration.
  • 基因功能參考文獻：
    1. CPAP regulates delivery of its bound beta-tubulin to define the size of microtubule-based cellular structures using a "clutch-like" mechanism. PMID: 27306797
    2. The TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and reinforces the sensitivity of the developing cerebellum to microtubule defects. PMID: 28013290
    3. At the cellular level, the p.Cys239Phe TUBB2B mutant leads to tubulin heterodimerization impairment, decreased ability to incorporate into the cytoskeleton, microtubule dynamics alteration, with an accelerated rate of depolymerization PMID: 26732629
    4. off-target, non-immune mediated effects of the mTOR-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 in glomerular podocyte development PMID: 26331477
    5. The association of polymicrogyria with thin or absent corpus callosum, dysmorphic basal ganglia, brainstem and vermis hypoplasia is highly likely to result from mutations in TUBB2B. PMID: 23495813
    6. The present study confirms that mutations in tubulin genes are responsible for complex brain malformation. PMID: 24392928
    7. Congenital fibrosis of the extraocular muscles and intellectual disability segregate with a heterozygous mutation in TUBB2B. PMID: 23001566
    8. The TUBB2B and TUBA1 coding regions have been sequenced in patients with cortical malformations associated with these genes. PMID: 23361065
    9. Three new TUBB2B mutations have been identified in three unrelated patients with a diffuse and rather symmetrical cortical abnormality. PMID: 22333901
    10. Brain malformations are associated with mutations in the beta-tubulin gene TUBB2B, supporting its critical role in migration/organization and axon guidance processes. PMID: 22591407
    11. TUBB2B is required for neuronal migration two disease-associated mutations lead to impaired formation of tubulin heterodimers. PMID: 19465910
    12. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    13. The class II beta-tubulin isotype seems to be a promising predictive marker of docetaxel activity in the treatment of breast neoplasms. PMID: 12533264
    14. The data suggest that the ratio of beta-tubulin classes II and V mRNA could be useful as a biomarker for NSCLC tumor differentiation and/or NSCLC aggressiveness. PMID: 18613117
    15. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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  • 相關疾病：
    Cortical dysplasia, complex, with other brain malformations 7 (CDCBM7); Fetal akinesia deformation sequence (FADS)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    High expression in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30829

    OMIM: 208150

    KEGG: hsa:347733

    STRING: 9606.ENSP00000259818

    UniGene: Hs.300701