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Tf Antibody, HRP conjugated

  • 中文名稱：
    Tf兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA856363LB01MO
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Tf Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Tf antibody; Trf antibody; Serotransferrin antibody; Transferrin antibody; Beta-1 metal-binding globulin antibody; Siderophilin antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Serotransferrin protein (401-697AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
  • 基因功能參考文獻(xiàn)：
    1. the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells. PMID: 27100851
    2. Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38. PMID: 26639305
    3. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. PMID: 23650374
    4. Together, these data indicate that Lcn2, in combination with transferrin, confines Klebsiella pneumoniae to the airways and prevents invasion into tissue containing the pulmonary vasculature. PMID: 23169997
    5. Transferrin(hpx/hpx) Hemojuvelin(+/+) and Transferrin(hpx/hpx) Hemojuvelin(-/-) phenotypes did not differ markedly, but RBC transfusions increased hepcidin levels in Transferrin(hpx/hpx) Hemojuvelin(+/+) but not Transferrin(hpx/hpx) Hemojuvelin(-/-)mice. PMID: 21993681
    6. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice. PMID: 22363754
    7. Neurodegenerative conditions involving iron-mediated toxicity may be due to a failure of iron transport or storage mechanisms, rather than to the presence of high levels of non-transferrin-bound iron. PMID: 20431983
    8. Apotransferrin mitigates the neurotoxicity of hemoglobin in a cell culture model of intracerebral hemorrhage. PMID: 21034753
    9. Descibed is the 2.4 A structure of inhibitor of carbonic anhydrase from a pseudomerohedral twinned crystal: a member of the transferrin superfamily. PMID: 20572014
    10. transferrin receptor 2 and HFE are involved in holotransferrin-dependent signaling for the regulation of furin which involved Erk phosphorylation. Furin in turn may control hepcidin expression. PMID: 20634490
    11. hepcidin expression in hypotransferrinemic mice is regulated both by transferrin-restricted erythropoiesis and by transferrin through a mechanism independent of its role in erythropoiesis PMID: 20956801
    12. These data show that mycobacteria reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to metabolizing transferrin and avoiding endocytosed immunoproteins like Lcn2. PMID: 20121435
    13. during later times postinfection (1.5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome PMID: 16611921
    14. Transsferrin overexpression has negative effects on testicular function and that transfserrin levels require strict regulation in the testis. PMID: 16998850
    15. developing erythroid cells, which are taking up vast amounts of Fe, deliver the metal directly from transferrin-containing endosomes to mitochondria PMID: 17376890
    16. The role of transferrin in glial protection was investigated. PMID: 18509548
    17. Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery. PMID: 19154717

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Transferrin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接：