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USP18 Antibody

  • 中文名稱：
    USP18兔多克隆抗體
  • 貨號(hào)：
    CSB-PA891559LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Mouse skeletal muscle tissue
      All lanes: USP18 antibody at 2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44, 42 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA891559LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891559LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA891559LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The USP18 antibody was derived from the rabbits immunized with the recombinant human USP18 protein (18-118aa). This rabbit anti-human USP18 polyclonal antibody was demonstrated to recognize human, and mouse USP18 proteins in ELISA, WB, IHC, and IF applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity.

    The target protein USP18 mainly regulates the immune response to viral infections and other inflammatory stimuli by deISGylating target proteins and inhibiting the interferon signaling pathway. Mutations in the USP18 gene can lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and type 1 diabetes, as well as susceptibility to viral infections.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) USP18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP18
  • 別名：
    43 kDa ISG15 specific protease antibody; 43 kDa ISG15-specific protease antibody; EC 3.1.2. antibody; hUBP43 antibody; Interferon Stimulated Gene 43 kD antibody; ISG15 Specific Processing Protease antibody; ISG15-specific-processing protease antibody; ISG43 antibody; Ubiquitin Specific Peptidase 18 antibody; Ubiquitin Specific Protease 18 43 kD antibody; Ubiquitin Specific Protease 18 antibody; Ubl carboxyl terminal hydrolase 18 antibody; Ubl carboxyl-terminal hydrolase 18 antibody; Ubl thioesterase 18 antibody; Ubl thiolesterase 18 antibody; Ubp15 antibody; UBP18_HUMAN antibody; USP18 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Ubl carboxyl-terminal hydrolase 18 protein (18-118AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，USP18 Antibody (CSB-PA891559LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于USP18 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA891559LB01HU USP18 Antibody, HRP conjugated ELISA
    FITC CSB-PA891559LC01HU USP18 Antibody, FITC conjugated
    Biotin CSB-PA891559LD01HU USP18 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the negative regulation of the inflammatory response triggered by type I interferon. Upon recruitment by STAT2 to the type I IFN receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I IFN signaling pathway. Also regulates protein ISGylation. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.; Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins.
  • 基因功能參考文獻(xiàn)：
    1. These results demonstrate that virus-induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18. Moreover, the data clearly demonstrate that DAA therapy restores IFN-alpha responsiveness in HCV-infected cells. PMID: 28630501
    2. The role of USP18 in breast cancer provides a novel insight into the clinical application of the USP18/AKT/Skp2 pathway. PMID: 29749454
    3. High expression levels of USP18 in the muscles of dermatomyositis patients. PMID: 27605457
    4. study preliminary elucidated the role of USP18 in hepatitis B virus replication and explored the potential key genes in USP18-mediated signaling pathway PMID: 28369997
    5. this study identified PTEN as a previously unrecognized substrate of the ISGylation post-translational modification pathway. The deconjugase USP18 serves as a novel regulator of PTEN stability. This indicates inhibition of ISGylation is therapeutically relevant in cancers. PMID: 27980214
    6. associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response PMID: 28718215
    7. that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells PMID: 28709980
    8. These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies PMID: 27325888
    9. We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10, and IRF7. An independent cohort confirmed LPS induction of USP41 and IL10 genes PMID: 27434537
    10. results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK/STAT signaling pathway in Hepg2.2.15 cells. PMID: 27227879
    11. USP18's ISG15 specificity is mediated by a small interaction interface. PMID: 28165509
    12. STAT2 recruits USP18 to the type I IFN receptor subunit IFNAR2 via its constitutive membrane-distal STAT2-binding site. PMID: 28165510
    13. findings show that multiple inflammatory stimuli can modulate interferon stimulated gene expression and thus inhibit hepatocyte interferon signaling via USP18 induction PMID: 27009955
    14. USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms. PMID: 26240016
    15. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2. PMID: 26046984
    16. Dimerization of IFNAR1 and IFNAR2 and the limiting role of IFNAR1 binding affinity in complex assembly is modulated by USP18. PMID: 26008745
    17. increased expression in the HIV+/HCV+ female patients group compared with HIV-/HCV+ and HIV+/HCV- groups PMID: 24955730
    18. USP18 expression levels induced by IFNbeta did not differ amongst multiple sclerosis patients carrying different rs2542109 genotypes PMID: 23700969
    19. USP18 inhibition induces inflammation by increasing the STAT signaling and exacerbates IFN-induced beta cell apoptosis. PMID: 23152055
    20. Usp18 upregulation was associated with Wilms Tumor. PMID: 23291318
    21. A direct relationship was found between UBP43 and cyclin D1 (but not cyclin E) expression. PMID: 22752428
    22. USP18 establishes the transcriptional and anti-proliferative interferon alpha/beta differential PMID: 22731491
    23. USP18 is up-regulated in liver samples of patients with chronic hepatitis C that did not respond to therapy, but not in patients with acute hepatitis C. PMID: 22677194
    24. although UBP43 depletion can cause hypersensitivity to interferon-alpha/beta-mediated apoptosis in a broad range of cell types, the downstream pathway may vary depending on the cell type. PMID: 22683641
    25. the existence of an N-terminal truncated isoform of USP18, whose expression is controlled on translational level by two independent mechanisms providing translational flexibility PMID: 22170061
    26. Inhibition of R. conorii-induced ISG15 by RNA interference results in significant increase in the extent of rickettsial replication, whereas UBP43 knockdown yields a reciprocal inhibitory effect. PMID: 22100648
    27. a model in which Usp18 inhibition promotes up-regulation of miR-7, which in turn inhibits EGFR expression and the tumorigenic activity of cancer cells. PMID: 21592959
    28. Findings define the ubiquitin protease UBP43 as a novel candidate drug target for APL treatment. PMID: 20935222
    29. Findings suggest that USP18 may significantly limit operation of the extrinsic apoptotic pathway triggered by type I IFN and drugs. PMID: 20068173
    30. UBP43 protein levels are regulated by proteolysis via the SCFSkp2 ubiquitin ligase PMID: 15342634
    31. Ubp43 deficiency increases the resistance to oncogenic transformation by BCR-ABL PMID: 17374743
    32. Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma PMID: 19551150

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  • 相關(guān)疾?。?/div>
    Pseudo-TORCH syndrome 2 (PTORCH2)
  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12616

    OMIM: 607057

    KEGG: hsa:11274

    STRING: 9606.ENSP00000215794

    UniGene: Hs.38260