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USP30 Antibody

  • 中文名稱：
    USP30兔多克隆抗體
  • 貨號：
    CSB-PA765106LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human Kidney tissue using CSB-PA765106LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA765106LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The polyclonal antibody against USP30 was created in rabbits through immunization with recombinant human USP30 protein containing amino acids 101-400. This USP30 polyclonal antibody is only reactive with USP30 protein from human samples. The deubiquitinase enzyme USP30 is responsible for the regulation of protein turnover and maintenance of mitochondrial function.

    The USP30 antibody has been purified via protein G affinity chromatography, achieving more than 95% purity. Its validation in ELISA and IHC applications has further enhanced its versatility in experimental settings.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) USP30 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，USP30 Antibody (CSB-PA765106LA01HU)，的標(biāo)記方式是Non-conjugated。對于USP30 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA765106LB01HU USP30 Antibody, HRP conjugated ELISA
    FITC CSB-PA765106LC01HU USP30 Antibody, FITC conjugated
    Biotin CSB-PA765106LD01HU USP30 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
  • 基因功能參考文獻(xiàn)：
    1. the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
    2. Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
    3. show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
    4. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
    5. The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
    6. reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
    7. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522

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  • 亞細(xì)胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Expressed in skeletal muscle, pancreas, liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20065

    OMIM: 612492

    KEGG: hsa:84749

    STRING: 9606.ENSP00000257548

    UniGene: Hs.486434