USP49 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q70CQ1
基因名：

USP49
別名：

USP49 antibody; Ubiquitin carboxyl-terminal hydrolase 49 antibody; EC 3.4.19.12 antibody; Deubiquitinating enzyme 49 antibody; Ubiquitin thioesterase 49 antibody; Ubiquitin-specific-processing protease 49 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human USP49
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
基因功能參考文獻：
1. Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT. PMID: 28363942
2. identifies USP49 as a histone H2B-specific deubiquitinase and uncovers a critical role for H2B deubiquitination in cotranscriptional pre-mRNA processing events. PMID: 23824326
亞細胞定位：

Nucleus.
蛋白家族：

Peptidase C19 family
數(shù)據(jù)庫鏈接：

HGNC: 20078

KEGG: hsa:25862

STRING: 9606.ENSP00000297229

UniGene: Hs.593575