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WDFY4 Antibody

  • 中文名稱(chēng)：
    WDFY4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA747798LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA747798LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA747798LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The WDFY4 polyclonal antibody is raised in rabbits against the peptide corresponding to amino acid residues 1-322 of the human WDFY4 protein. It occurs as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it only reacts with human WDFY4 protein. Validations of this antibody have been done in ELISA and IHC assays. The target protein WDFY4 is required for the cross-presentation of cell- and bacterial-associated antigens. It also plays a key role in cDC1-mediated viral and tumor immunity.

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) WDFY4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WDFY4
  • 別名：
    WDFY4 antibody; C10orf64 antibody; KIAA1607WD repeat- and FYVE domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human WD repeat- and FYVE domain-containing protein 4 protein (1-322AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，WDFY4 Antibody (CSB-PA747798LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于WDFY4 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA747798LB01HU WDFY4 Antibody, HRP conjugated ELISA
    FITC CSB-PA747798LC01HU WDFY4 Antibody, FITC conjugated
    Biotin CSB-PA747798LD01HU WDFY4 Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy.
  • 基因功能參考文獻(xiàn)：
    1. A significantly increased risk for RA associated with the WDFY4 rs7097397 AG genotype. PMID: 24549174
    2. rs877819 SNP in WDFY4 may be associated with systemic lupus erythematosus by reduced binding of YY1 and downregulating WDFY4 expression. PMID: 22972472
    3. Genetic variants in ETS1 and WDFY4 were found to be associated with systemic lupus erythematosus, in the Asian population studied. PMID: 20169177
  • 亞細(xì)胞定位：
    Early endosome. Endoplasmic reticulum.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29323

    OMIM: 613316

    KEGG: hsa:57705

    STRING: 9606.ENSP00000320563

    UniGene: Hs.287379