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XKR8 Antibody

  • 中文名稱：
    XKR8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA875681LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate(20μg), 293T whole cell lysate(20μg), PC-3 whole cell lysate(20μg), JK whole cell lysate(20μg), MCF7 whole cell lysate(20μg)
      All lanes: XKR8 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 39, 44.6 kDa
      Observed band size: 39 kDa
      Exposure time: 120s
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The product CSB-PA875681LA01HU is a polyclonal antibody raised in the rabbit against a partial recombinant protein corresponding to 69-158 amino acids of human XKR8 protein. It exists as the unconjugated IgG isoform. It only reacts with human samples. This XKR8 antibody was purified by protein G affinity chromatography with a purity of up to 95%. And it has tested its specificity and reliability in ELISA, WB, IHC, and IF applications.

    Its target protein XKR8 appears to play a role in cellular adhesion, migration, invasion, and survival. Its interactions with key regulators of these processes suggest that it may have important implications for the development and progression of cancer and other diseases.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) XKR8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    XKR8
  • 別名：
    FLJ10307 antibody; hXkr8 antibody; RP11-460I13.3 antibody; X Kell blood group precursor-related family; member 8 antibody; XK-related protein 8 antibody; XKR8 antibody; XKR8_HUMAN antibody; XRG8 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human XK-related protein 8 protein (69-158AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，XKR8 Antibody (CSB-PA875681LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于XKR8 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA875681LB01HU XKR8 Antibody, HRP conjugated ELISA
    FITC CSB-PA875681LC01HU XKR8 Antibody, FITC conjugated
    Biotin CSB-PA875681LD01HU XKR8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina. Has no effect on calcium-induced exposure of phosphatidylserine. Promotes myoblast differentiation and survival.; (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles. Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells.
  • 基因功能參考文獻(xiàn)：
    1. Xkr8-BSG/NPTN complex is required for phosphatidylserine scrambling in apoptotic cell membranes. PMID: 27503893
    2. The Xkr8 influences myogenesis by acting as a positive regulator of terminal differentiation and myoblast survival. PMID: 28881496
    3. facilitates transbilayer migration of lipids [review] PMID: 26936867
    4. findings show the Xk-family protein Xkr8 mediates phosphatidylserine exposure in response to apoptotic stimuli; Xk-family proteins have evolutionarily conserved roles in promoting phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane PMID: 23845944
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    XK family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25508

    KEGG: hsa:55113

    STRING: 9606.ENSP00000362991

    UniGene: Hs.55024