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ZDHHC6 Antibody

  • 中文名稱(chēng)：
    ZDHHC6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA862029LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: 3T3 whole cell lysate(20μg), HL60 whole cell lysate(20μg), RAW264.7 whole cell lysate(20μg), 293T whole cell lysate(20μg), HELA whole cell lysate(20μg), MCF7 whole cell lysate(20μg), Mouse Brain tissue lysate(20μg)
      All lanes: ZDHHC6 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47.6 kDa
      Observed band size: 48 kDa
      Exposure time：30s
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) ZDHHC6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZDHHC6
  • 別名：
    ZDHHC6; ZNF376; Palmitoyltransferase ZDHHC6; Stearoyltransferase ZDHHC6; Transmembrane protein H4; Zinc finger DHHC domain-containing protein 6; DHHC-6; Zinc finger protein 376
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Palmitoyltransferase ZDHHC6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation.
  • 基因功能參考文獻(xiàn)：
    1. human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade. PMID: 28826475
    2. DHHC6 knockdown using shRNA in stably transfected cell lines led to decreased expression of the IP3R and impaired IP3R-dependent Ca(2+) flux. PMID: 25368151
    3. Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain. PMID: 19801377
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    DHHC palmitoyltransferase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19160

    KEGG: hsa:64429

    STRING: 9606.ENSP00000358413

    UniGene: Hs.196990