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  4. ZNF24 Antibody

ZNF24 Antibody

  • 中文名稱：
    ZNF24兔多克隆抗體
  • 貨號：
    CSB-PA003108
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using KOX17 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ZNF24
  • 別名：
    KOX17 antibody; Retinoic acid suppression protein A antibody; RSG A antibody; RSG-A antibody; RSGA antibody; Zfp191 antibody; Zinc finger and SCAN domain containing protein 3 antibody; Zinc finger and SCAN domain-containing protein 3 antibody; Zinc finger protein 191 antibody; Zinc finger protein 24 antibody; Zinc finger protein KOX17 antibody; ZNF 24 antibody; ZNF191 antibody; ZNF24 antibody; ZNF24_HUMAN antibody; ZSCAN 3 antibody; ZSCAN3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human KOX17.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro.
  • 基因功能參考文獻：
    1. miR-940 promoted gastric cancer progression by directly downregulating ZNF24 expression. PMID: 26317898
    2. In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks. PMID: 25550468
    3. results suggest that consecutive ZF1-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function. PMID: 24224020
    4. ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z. PMID: 22678762
    5. ZNF191 can directly bind to the CTNNB1 promoter and activate the expression of beta-catenin and its downstream target genes such as cyclin D1 in hepatoma cell lines. PMID: 22213192
    6. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription. PMID: 20510677
    7. Overexpression and purification of single zinc finger peptides of ZNF191 were performed. PMID: 17270462
    8. ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development, and tumor growth. PMID: 19463170
    9. Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage. PMID: 19544452

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed in many tissues except in heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13032

    OMIM: 194534

    KEGG: hsa:7572

    STRING: 9606.ENSP00000261332

    UniGene: Hs.514802