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CARS Recombinant Monoclonal Antibody

  • 中文名稱：
    CARS重組抗體
  • 貨號：
    CSB-RA158403A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, Jurkat whole cell lysate
      All lanes: CARS antibody at 1:500
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 86, 83, 95 kDa
      Observed band size: 95 kDa
  • 其他：

產品詳情

  • 產品描述：
    CARS Recombinant Monoclonal Antibody（CSB-RA158403A0HU）是針對人源CARS蛋白研發(fā)的高特異性重組單克隆抗體，適用于ELISA和Western Blot（WB）等免疫檢測實驗。CARS（Cysteinyl-tRNA Synthetase）是細胞質氨基酰-tRNA合成酶家族成員，負責催化半胱氨酸與其對應tRNA的結合，在蛋白質翻譯過程中發(fā)揮關鍵作用，并與氧化應激調控、細胞代謝等生物學過程密切相關。本抗體經嚴格驗證，在WB實驗中可特異性識別天然狀態(tài)下的人源CARS蛋白，推薦使用稀釋比例為1:500至1:2000，實驗結果顯示清晰的單一目標條帶，且不同批次間穩(wěn)定性優(yōu)異，能夠有效檢測多種哺乳動物細胞或組織樣本中的內源性CARS表達。該產品適用于探索CARS在蛋白質合成調控、氧化應激反應及代謝相關疾病機制中的功能研究，可廣泛應用于基因表達分析、信號通路研究及分子互作實驗等基礎科研領域，為研究者在細胞生物學、分子病理學等方向提供可靠的工具支持。
  • Uniprot No.：
  • 基因名：
    CARS
  • 別名：
    Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS), CARS
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human CARS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8B11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
  • 基因功能參考文獻：
    1. Four single nucleotide polymorphisms (SNPs) of CARS were significantly associated with gastric cancer risk in both the discovery stage and the validation stage PMID: 28409418
    2. The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05). PMID: 26909942
    3. Loss of CARS, the cysteinyl-tRNA synthetase, suppresses ferroptosis induced by erastin, which inhibits the cystine-glutamate antiporter known as system xc(-). PMID: 26184909
    4. CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. PMID: 12112524
    5. Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. PMID: 17303165

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  • 相關疾?。?/div>
    A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1493

    OMIM: 123859

    KEGG: hsa:833

    STRING: 9606.ENSP00000369897

    UniGene: Hs.274873