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CBX2 Recombinant Monoclonal Antibody

  • 中文名稱：
    CBX2重組抗體
  • 貨號(hào)：
    CSB-RA632623A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate, Ntera-2 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, HEK293 whole cell lysate, Rat heart tissue
      All lanes: CBX2 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57, 24 kDa
      Observed band size: 60-72 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA632623A0HU重組單克隆抗體是針對(duì)表觀遺傳調(diào)控核心因子CBX2開發(fā)的高特異性科研工具。該抗體靶向Polycomb抑制復(fù)合物（PRC1）的關(guān)鍵成員CBX2蛋白，該蛋白通過介導(dǎo)組蛋白H3K27me3修飾參與基因沉默、干細(xì)胞維持及細(xì)胞命運(yùn)決定等重要生物學(xué)過程，其功能異常與胚胎發(fā)育異常及腫瘤發(fā)生密切相關(guān)。經(jīng)嚴(yán)格驗(yàn)證，本抗體在Western Blot實(shí)驗(yàn)中可清晰識(shí)別內(nèi)源性CBX2蛋白表達(dá)，推薦使用濃度為1:500至1:2000；同時(shí)具備ELISA檢測(cè)應(yīng)用兼容性，為研究者提供多重實(shí)驗(yàn)選擇。該產(chǎn)品適用于探索多能性維持、細(xì)胞重編程、腫瘤表觀遺傳失調(diào)等研究領(lǐng)域，尤其適用于染色質(zhì)動(dòng)態(tài)調(diào)控機(jī)制解析、基因沉默模型構(gòu)建及靶向PRC1復(fù)合物的功能研究。通過高批間一致性和低交叉反應(yīng)性的優(yōu)勢(shì)，該抗體可為表觀遺傳學(xué)、發(fā)育生物學(xué)和腫瘤微環(huán)境研究提供可靠支持，所有應(yīng)用均嚴(yán)格限定于基礎(chǔ)科研范疇。
  • Uniprot No.：
  • 基因名：
    CBX2
  • 別名：
    Chromobox protein homolog 2, CBX2
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    A synthesized peptide derived from human CBX2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    24A2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
  • 基因功能參考文獻(xiàn)：
    1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management. PMID: 29998616
    2. These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes. PMID: 28992316
    3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2. PMID: 26431491
    4. up-regulated in metastatic castration-resistant prostate cancer and elevated expression correlates with poor clinical outcome PMID: 26877821
    5. CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway. PMID: 25569159
    6. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast PMID: 25225902
    7. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development. PMID: 23219007
    8. Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex. PMID: 22419124
    9. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin PMID: 22009739
    10. hPc2 serves as a SUMO E3 ligase for cystathionine beta-synthase, increasing the efficiency of sumoylation. PMID: 19107218

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  • 相關(guān)疾?。?/div>
    46,XY sex reversal 5 (SRXY5)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1552

    OMIM: 602770

    KEGG: hsa:84733

    STRING: 9606.ENSP00000308750

    UniGene: Hs.368410