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CD37 Recombinant Monoclonal Antibody

  • 中文名稱(chēng):
    CD37重組抗體
  • 貨號(hào):
    CSB-RA004928MA1HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • IHC image of CSB-RA004928MA1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    CSB-RA004928MA1HU CD37重組單克隆抗體是針對(duì)人源CD37抗原設(shè)計(jì)的高特異性科研工具。CD37作為四次跨膜蛋白家族成員,在B淋巴細(xì)胞表面特異性表達(dá),參與調(diào)控細(xì)胞黏附、遷移及信號(hào)轉(zhuǎn)導(dǎo),其異常表達(dá)與B細(xì)胞淋巴瘤等疾病密切相關(guān)。本抗體經(jīng)ELISA及免疫組化(IHC)雙重平臺(tái)驗(yàn)證,在IHC應(yīng)用中可清晰顯示石蠟包埋組織中B淋巴細(xì)胞的膜定位特征,推薦使用稀釋度為1:50-1:200,能有效區(qū)分目標(biāo)蛋白的組織分布差異。ELISA檢測(cè)體系顯示其具備出色的線性反應(yīng)范圍,適用于體外樣本的定量分析。該產(chǎn)品可為B細(xì)胞發(fā)育分化研究、淋巴瘤微環(huán)境分析、免疫細(xì)胞表面標(biāo)記物檢測(cè)等實(shí)驗(yàn)提供可靠支持,尤其在探究B細(xì)胞相關(guān)疾病的分子機(jī)制、篩選潛在治療靶點(diǎn)及開(kāi)發(fā)體外檢測(cè)方法等領(lǐng)域具有重要應(yīng)用價(jià)值。通過(guò)嚴(yán)格的抗原親和純化工藝,確保批次間穩(wěn)定性,適用于需要高重復(fù)性的長(zhǎng)期研究項(xiàng)目。
  • Uniprot No.:
  • 基因名:
  • 別名:
    CD37 Recombinant Monoclonal Antibody
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human CD37 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類(lèi)型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號(hào):
    9H6
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
    2. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
    3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
    4. Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
    5. Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
    6. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
    7. CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
    8. CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
    9. provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052

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  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Tetraspanin (TM4SF) family
  • 組織特異性:
    B-lymphocytes.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 1666

    OMIM: 151523

    KEGG: hsa:951

    STRING: 9606.ENSP00000325708

    UniGene: Hs.166556