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CDH6 Recombinant Monoclonal Antibody

  • 中文名稱：
    CDH6重組抗體
  • 貨號：
    CSB-RA005055MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH6 (CSB-MP005055HU1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 2.421-2.802 ng/mL.
    • The Binding Activity of Mouse CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse CDH6 (CSB-MP005055MO1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 1.884-2.164 ng/mL.
    • The Binding Activity of Rat CDH6 with Anti-CDH6 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat CDH6 (CSB-MP005055RA1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC50 is 1.630-1.837 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CDH6重組單克隆抗體（CSB-RA005055MA1HU）是針對鈣黏蛋白家族成員CDH6開發(fā)的高特異性科研工具。CDH6是一種跨膜糖蛋白，主要參與細(xì)胞間黏附及信號轉(zhuǎn)導(dǎo)調(diào)控，在胚胎發(fā)育、器官形成及部分腫瘤微環(huán)境重塑中發(fā)揮重要作用。本抗體采用重組技術(shù)制備，具有優(yōu)異的批次穩(wěn)定性，經(jīng)ELISA方法嚴(yán)格驗(yàn)證，可實(shí)現(xiàn)對CDH6蛋白的特異性識別，適用于體外樣本中靶標(biāo)蛋白的定量檢測與分析。在科研領(lǐng)域，該產(chǎn)品可應(yīng)用于腫瘤生物學(xué)研究中CDH6表達(dá)模式的探索，例如在腎癌、卵巢癌等模型中的功能機(jī)制研究；同時支持細(xì)胞黏附實(shí)驗(yàn)、遷移侵襲實(shí)驗(yàn)等體外研究，為解析CDH6在組織穩(wěn)態(tài)維持及病理狀態(tài)下的調(diào)控網(wǎng)絡(luò)提供可靠工具。該抗體還可與其他分子生物學(xué)技術(shù)聯(lián)用，助力于疾病相關(guān)信號通路的分子機(jī)制解析。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CDH6 Recombinant Monoclonal Antibody
  • 反應(yīng)種屬：
    Human, Macaca fascicularis, Rat
  • 免疫原：
    Recombinant Human CDH6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8B4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻(xiàn)：
    1. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC PMID: 27593557
    2. The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. PMID: 20634887
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1765

    OMIM: 603007

    KEGG: hsa:1004

    STRING: 9606.ENSP00000265071

    UniGene: Hs.124776