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CLEC4C Recombinant Monoclonal Antibody

  • 中文名稱(chēng)：
    CLEC4C重組抗體
  • 貨號(hào)：
    CSB-RA855470MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of CLEC4C with anti-CLEC4C antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C (CSB-MP855470HUh7) at 2 μg/mL can bind Anti-CLEC4C recombinant antibody，the EC50 is 7.658-12.99 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA855470MA1HU是針對(duì)CLEC4C靶點(diǎn)開(kāi)發(fā)的重組單克隆抗體，該靶點(diǎn)又稱(chēng)CD303或BDCA-2，屬于C型凝集素受體家族成員，主要在漿細(xì)胞樣樹(shù)突狀細(xì)胞（pDC）表面特異性表達(dá)，通過(guò)識(shí)別病原體相關(guān)分子模式參與先天免疫應(yīng)答，并在調(diào)控I型干擾素分泌、抗病毒免疫及自身免疫性疾病發(fā)生中發(fā)揮關(guān)鍵作用。本抗體通過(guò)ELISA驗(yàn)證，展現(xiàn)出高特異性和靈敏度，可有效識(shí)別天然及重組表達(dá)的CLEC4C蛋白，適用于體外研究該分子在免疫調(diào)節(jié)中的功能機(jī)制。其應(yīng)用場(chǎng)景包括探索病毒感染中pDC的激活途徑、自身免疫性疾?。ㄈ缦到y(tǒng)性紅斑狼瘡）的分子機(jī)制，以及腫瘤微環(huán)境中免疫細(xì)胞相互作用的研究，為解析CLEC4C介導(dǎo)的信號(hào)通路、開(kāi)發(fā)相關(guān)免疫調(diào)控策略提供可靠工具。本產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，包括但不限于蛋白質(zhì)互作分析、細(xì)胞功能研究及體外分子檢測(cè)等實(shí)驗(yàn)體系。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303), CLEC4C, BDCA2 CLECSF11 CLECSF7 DLEC HECL
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC4C protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    7B8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
  • 基因功能參考文獻(xiàn)：
    1. Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. PMID: 29796630
    2. decrease in the surface expression of CLEC4C and the endoplasmic reticulum localization of the mutant construct were observed PMID: 26943047
    3. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. PMID: 25779340
    4. BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. PMID: 25995448
    5. We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). PMID: 24425442
    6. Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. PMID: 24829416
    7. Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). PMID: 23053572
    8. Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. PMID: 21880719
    9. Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques. PMID: 21436634
    10. Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
    11. Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes PMID: 19829303
    12. Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells. PMID: 17850179
    13. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 and cytoskeletal proteins. CD303 signaling is linked with internalization by clathrin-mediated endocytosis. PMID: 18022864
    14. results suggest that downregulation of BDCA2 expression on plasmacytoid dendritic cells (pDCs) may reflect the activation of pDCs accumulated in systemic lupus erythematosus patients & may be one marker for indication of disease activity of SLE patients PMID: 18684674
    15. Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. PMID: 19577819

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13258

    OMIM: 606677

    KEGG: hsa:170482

    STRING: 9606.ENSP00000353500

    UniGene: Hs.351812