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CLEC9A Recombinant Monoclonal Antibody

  • 中文名稱：
    CLEC9A Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA740922MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CLEC9A with Anti-CLEC9A recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CLEC9A recombinant antibody at 2 μg/mL can bind Human CLEC9A protein (CSB-MP740922HU-B). The EC50 is 2.915-3.520 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CLEC9A重組單克隆抗體（CUSABIO貨號(hào)：CSB-RA740922MA1HU）是一款針對(duì)CLEC9A靶點(diǎn)設(shè)計(jì)的高特異性科研工具。CLEC9A是C型凝集素家族成員，主要表達(dá)于樹突狀細(xì)胞表面，通過識(shí)別死亡細(xì)胞釋放的肌動(dòng)蛋白相關(guān)分子參與抗原交叉提呈，在啟動(dòng)適應(yīng)性免疫應(yīng)答中發(fā)揮關(guān)鍵作用。本抗體經(jīng)ELISA嚴(yán)格驗(yàn)證，推薦工作稀釋度為1:5000至1:50000，可高效識(shí)別天然構(gòu)象下的靶蛋白，展現(xiàn)優(yōu)異的靈敏度和低背景特性。適用于體外實(shí)驗(yàn)中對(duì)CLEC9A蛋白的定量檢測(cè)、免疫調(diào)控機(jī)制研究以及樹突狀細(xì)胞相關(guān)功能分析，為免疫學(xué)、腫瘤微環(huán)境研究及感染性疾病模型構(gòu)建提供可靠支持。該產(chǎn)品采用重組單克隆抗體技術(shù)，確保批次間一致性，適用于需要高重復(fù)性的實(shí)驗(yàn)體系。僅供科學(xué)研究使用，不適用于臨床診斷或其他用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C type lectin domain family 9; member A antibody; C-type lectin domain family 9 member A antibody; CLC9A_HUMAN antibody; CLEC9A antibody; DNGR1 antibody; HEEE9341 antibody; PRO34046 antibody; UNQ9341 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CLEC9A protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG4(S228P)
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    9H7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy PMID: 27250027
    2. findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection PMID: 29065139
    3. Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity. PMID: 24910448
    4. Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease. PMID: 24049150
    5. study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity PMID: 22483800
    6. High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans. PMID: 22442345
    7. propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines. PMID: 22483802
    8. Data show that CLEC9A is only expressed on immature BDCA3(+) myeloid dendritic cells (mDCs). PMID: 22234694
    9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. A population of human dendritic cells (DC) that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function, is characterized. PMID: 20479117
    11. DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group PMID: 18497879
    12. CLEC9A functions as an activation receptor PMID: 18408006
    13. analysis of differences between mouse and human Clec9A PMID: 18669894
    14. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens PMID: 19219027
    15. The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110) is the first characterization of human and mouse CLEC9A (a.k.a DNGR-1) PMID: 18497879

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 組織特異性：
    In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26705

    OMIM: 612252

    KEGG: hsa:283420

    STRING: 9606.ENSP00000348074

    UniGene: Hs.531189