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GIPR Recombinant Monoclonal Antibody

  • 中文名稱：
    GIPR重組抗體
  • 貨號(hào)：
    CSB-RA009438MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Macaca fascicularis GIPR with Anti-GIPR recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis GIPR (CSB-YP4825MOV) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 12.66-13.86 ng/mL.
    • The Binding Activity of Human GIPR with Anti-GIPR recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GIPR (CSB-MP009438HU1d7) at 2 μg/mL can bind Anti-GIPR recombinant antibody. The EC50 is 16.18-18.70 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA009438MA1HU GIPR重組單克隆抗體是針對(duì)胃抑制多肽受體（Gastric Inhibitory Polypeptide Receptor）開發(fā)的高特異性科研工具。該受體屬于G蛋白偶聯(lián)受體超家族，主要表達(dá)于胰腺β細(xì)胞、脂肪細(xì)胞及中樞神經(jīng)系統(tǒng)，通過介導(dǎo)GIP激素信號(hào)參與葡萄糖穩(wěn)態(tài)調(diào)節(jié)、脂質(zhì)代謝及能量平衡等生理過程，其功能異常與2型糖尿病、肥胖癥等代謝性疾病密切相關(guān)。本抗體經(jīng)ELISA平臺(tái)嚴(yán)格驗(yàn)證，展現(xiàn)出優(yōu)異的結(jié)合活性和批次穩(wěn)定性，可精準(zhǔn)識(shí)別天然構(gòu)象的GIPR蛋白，適用于體外檢測(cè)、靶蛋白定量分析及受體功能研究等實(shí)驗(yàn)場(chǎng)景。研究人員可利用該抗體開展代謝調(diào)控機(jī)制探索、受體表達(dá)模式分析或相關(guān)藥物靶點(diǎn)篩選等基礎(chǔ)研究，為深入解析GIPR在能量代謝網(wǎng)絡(luò)中的作用提供可靠檢測(cè)手段。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Gastric inhibitory polypeptide receptor, GIPR
  • 反應(yīng)種屬：
    Human, Macaca fascicularis
  • 免疫原：
    Recombinant Human GIPR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG4
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    15D4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻(xiàn)：
    1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
    2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
    3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
    4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
    5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
    6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
    7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
    8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
    10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
    11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
    12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
    13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
    14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
    16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
    17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
    18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
    19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
    21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
    22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
    23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
    24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
    25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
    26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
    27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
    28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
    29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
    30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
    31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4271

    OMIM: 137241

    KEGG: hsa:2696

    STRING: 9606.ENSP00000467494

    UniGene: Hs.251412