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  4. IL1RAP Recombinant Monoclonal Antibody

IL1RAP Recombinant Monoclonal Antibody

  • 中文名稱：
    IL1RAP重組抗體
  • 貨號：
    CSB-RA878844MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Macaca fascicularis IL1RAP with Anti-IL1RAP recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL1RAP (CSB-MP5268MOV) at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9099-1.181 ng/mL.
    • The Binding Activity of Human IL1RAP with Anti-IL1RAP recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP (CSB-MP878844HU) at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9667-1.477 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA878844MA1HU IL1RAP重組單克隆抗體是針對白細胞介素-1受體輔助蛋白（IL1RAP）研發(fā)的高特異性科研工具，適用于ELISA檢測體系，推薦使用稀釋比例為1:5000至1:50000。該抗體通過重組表達技術(shù)制備，具有嚴格的批間一致性，其靶向的IL1RAP作為IL-1信號通路的關(guān)鍵共受體分子，在先天免疫應(yīng)答、炎癥調(diào)控及腫瘤微環(huán)境調(diào)節(jié)中發(fā)揮重要作用。經(jīng)嚴格驗證，該產(chǎn)品在ELISA實驗中展現(xiàn)出優(yōu)異的抗原結(jié)合能力與低交叉反應(yīng)性，可精準檢測天然及重組形式的人源IL1RAP蛋白。適用于體外研究IL-1介導(dǎo)的炎癥級聯(lián)反應(yīng)、免疫細胞激活機制，或用于腫瘤相關(guān)信號通路的功能性研究，為探索炎癥性疾病、自身免疫疾病及腫瘤免疫調(diào)控提供可靠的工具支持，實驗結(jié)果需結(jié)合其他實驗方法進一步驗證。本產(chǎn)品僅限科研使用。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C3orf13 antibody; FLJ37788 antibody; IL 1 receptor accessory protein antibody; IL 1R 3 antibody; IL 1R3 antibody; IL 1RAcP antibody; IL 1RAP antibody; IL-1 receptor accessory protein antibody; IL-1R-3 antibody; IL-1R3 antibody; IL-1RAcP antibody; IL-1RAP antibody; IL1 receptor accessory protein antibody; IL1AP_HUMAN antibody; IL1R3 antibody; IL1RAcP antibody; Il1rap antibody; Interleukin 1 Accessory Protein antibody; interleukin 1 receptor 3 antibody; Interleukin 1 receptor accessory protein antibody; interleukin 1 receptor accessory protein beta antibody; Interleukin-1 receptor 3 antibody; Interleukin-1 receptor accessory protein antibody
  • 反應(yīng)種屬：
    Human, Macaca fascicularis
  • 免疫原：
    Recombinant Human IL1RAP protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2G7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).; Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.; Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
  • 基因功能參考文獻：
    1. Expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas PMID: 29238884
    2. These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. PMID: 27621309
    3. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    4. The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework. PMID: 26268530
    5. The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk. PMID: 25517029
    6. Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis. PMID: 24935223
    7. Plasma sIL1RAP levels are reduced in obesity and can potentially act as biomarkers of obesity. PMID: 24915116
    8. Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution. PMID: 23980170
    9. Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells. PMID: 22723552
    10. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. PMID: 22778412
    11. decreased protein levels in the peritoneal fluid of women with endometriosis PMID: 21958553
    12. Studies indicate that new targets have recently been investigated as potential modulators in myeloid leukemia pathogenesis, including miR-328, BMI1, FOXOs and IL1RAP. PMID: 21373837
    13. This study showed a significant downregulation of soluble interleukin-1 receptor accessory protein expression in the endometrium of women with endometriosis. PMID: 21272866
    14. identifies IL1RAP as a unique cell surface biomarker distinguishing Ph(+) from Ph(-) candidate chronic myeloid leukemia (CML) stem cells and opens up a previously unexplored avenue for therapy of CML PMID: 20805474
    15. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling PMID: 11880380
    16. soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor PMID: 12530978
    17. The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation. PMID: 12781872
    18. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP in Jurkat cells PMID: 14734551
    19. Specific destabilization of membrane-bound IL-1 receptor accessory protein mRNA in HepG2 hepatoma cells is mediated by its 2.8-kilobase 3'-untranslated region. PMID: 15528363
    20. Analysis of a three-dimensional docking model of the TIR-TIR interaction between MyD88 and IL1RAcP PMID: 15849357
    21. IL-1ra is associated with preserved beta-cell capacity in type 1 diabetes. PMID: 18299313
    22. an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS. PMID: 19481478

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  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5995

    OMIM: 602626

    KEGG: hsa:3556

    UniGene: Hs.478673