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KDM1B Recombinant Monoclonal Antibody

  • 中文名稱：
    KDM1B重組抗體
  • 貨號(hào)：
    CSB-RA958367A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate
      All lanes: KDM1B antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 93, 66, 20 kDa
      Observed band size: 90-95, 17-28 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    KDM1B Recombinant Monoclonal Antibody（CSB-RA958367A0HU）是針對(duì)組蛋白修飾酶KDM1B（賴氨酸特異性去甲基酶1B）開(kāi)發(fā)的高特異性科研工具，適用于表觀遺傳調(diào)控機(jī)制研究。該抗體通過(guò)重組技術(shù)制備，具有優(yōu)異的批次一致性和穩(wěn)定性，經(jīng)ELISA和Western Blot（WB）嚴(yán)格驗(yàn)證，在1:500-1:2000稀釋范圍內(nèi)可清晰檢測(cè)內(nèi)源性KDM1B蛋白，特異性經(jīng)重組蛋白對(duì)照實(shí)驗(yàn)確認(rèn)。KDM1B作為H3K4me1/2去甲基化酶，在胚胎發(fā)育、干細(xì)胞多能性維持及腫瘤發(fā)生中發(fā)揮重要調(diào)控作用。本產(chǎn)品適用于檢測(cè)哺乳動(dòng)物細(xì)胞裂解液或組織樣本中KDM1B的表達(dá)水平，可支持表觀遺傳學(xué)、細(xì)胞分化、腫瘤生物學(xué)等領(lǐng)域的機(jī)制研究，尤其在探索基因沉默、染色質(zhì)重塑及異常表觀遺傳修飾相關(guān)疾病模型中具有應(yīng)用價(jià)值。實(shí)驗(yàn)建議配合陽(yáng)性對(duì)照驗(yàn)證樣本處理?xiàng)l件，避免交叉反應(yīng)干擾。
  • Uniprot No.：
  • 基因名：
    KDM1B
  • 別名：
    Lysine-specific histone demethylase 1B (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 2), KDM1B, AOF1 C6orf193 LSD2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human KDM1B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    15F3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
  • 基因功能參考文獻(xiàn)：
    1. These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. PMID: 29845195
    2. This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. PMID: 28277979
    3. These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. PMID: 24924415
    4. Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. PMID: 25773598
    5. Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. PMID: 25624347
    6. regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 PMID: 25036127
    7. The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. PMID: 23266887
    8. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. PMID: 20670891

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21577

    OMIM: 613081

    KEGG: hsa:221656

    STRING: 9606.ENSP00000297792

    UniGene: Hs.709336