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KRT10 Recombinant Monoclonal Antibody

  • 中文名稱：
    KRT10重組抗體
  • 貨號：
    CSB-RA582749A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA582749A0HU diluted at 1:50 and staining in paraffin-embedded human pancreati tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.34% DAB.
    • IHC image of CSB-RA582749A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.34% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA582749A0HU人源KRT10重組單克隆抗體是針對角蛋白10（Keratins 10）設(shè)計的高特異性科研工具。該抗體靶向的表皮分化標(biāo)志物KRT10屬于I型角蛋白家族，在皮膚終末分化過程中發(fā)揮關(guān)鍵作用，通過維持上皮細(xì)胞機(jī)械穩(wěn)定性參與屏障功能調(diào)控。本產(chǎn)品經(jīng)ELISA和免疫組化（IHC）嚴(yán)格驗(yàn)證，在人類皮膚組織樣本中展現(xiàn)出優(yōu)異的胞質(zhì)定位效果，推薦IHC使用濃度為1:50-1:200，其線性表位識別能力確保檢測信號的精準(zhǔn)性和可重復(fù)性。該抗體適用于研究表皮發(fā)育異常、角化障礙性疾?。ㄈ缦忍煨贼~鱗?。┮约澳[瘤上皮分化特征的機(jī)制探索，可配合石蠟包埋組織切片或細(xì)胞樣本進(jìn)行形態(tài)學(xué)分析，或在ELISA平臺實(shí)現(xiàn)目標(biāo)蛋白的定量檢測。通過重組表達(dá)技術(shù)生產(chǎn)的單克隆抗體具有批次間高度一致性，經(jīng)多級純化工藝去除交叉反應(yīng)組分，為皮膚生物學(xué)、病理學(xué)及再生醫(yī)學(xué)研究提供穩(wěn)定可靠的研究工具，本產(chǎn)品僅限于科學(xué)研究使用。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10), KRT10, KPP
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human KRT10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
  • 基因功能參考文獻(xiàn)：
    1. The molecular diagnostics by the whole exome sequencing showed a novel de novo (c.1374-2A>C) mutation in the KRT10 gene responsible for the development of IWC (KRT10 defect was confirmed by immunofluorescent study). Concurrently, the m.14484T>C mutation in mitochondrial MTND6 gene (characteristic for Leber's hereditary optic neuropathy or LHON) was detected in patient, his mother and brother PMID: 28944608
    2. KRT10 gene mutation was present in all of the affected individuals, but absent in the five unaffected and 100 ethnically-matched healthy controls. PMID: 27212473
    3. Mutations in the highly conserved helix initiation motif of K10 were associated with mild or severe form of epidermolytic ichthyosis PMID: 26373619
    4. Report genetic/clinical spectrum of KRT10 mutations in keratinopathic ichthyosis. PMID: 26581228
    5. We present an autosomal dominant pedigree with epidermolytic ichthyosis resulting from a new heterozygous missense mutation in keratin 10. PMID: 26338057
    6. recombinant adenovirus-mediated overexpression of KRT10 and PTEN may improve the cisplatin resistance of ovarian cancer in vitro and in vivo PMID: 26125866
    7. findings provide structural insights into phenotypic variation in epidermolytic ichthyosis due to KRT10 mutations PMID: 26176760
    8. The diagnosis of ichthyosis with confetti was confirmed by the identification of 2 previously unreported mutations in intron 6 and exon 7 of KRT10. PMID: 24626314
    9. We present the spectrum of clinical variability of ichthyosis with confetti in 6 patients with confirmed mutations in KRT10. PMID: 25210931
    10. Case Report: extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis. PMID: 24096702
    11. Data indicate that KRT10 is a downstream molecule of PTEN which improves cisplatin-resistance of ovarian cancer cells. PMID: 24434152
    12. Most of the orthokeratotic dysplasia constituent cells were immunopositive for keratin 10, but not for keratins 13, 17 or 19. PMID: 22734720
    13. Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin play the role in pathogenesis of leprosy. PMID: 23121977
    14. Pneumococcal ligands K10, laminin receptor and platelet-activating factor receptor are elevated in aged lungs and contribute to the enhanced susceptibility to pneumonia. PMID: 21615674
    15. mapping and identifying disease-causing mutations in gene encoding KRT10 in ichthyosis with confetti; high frequency of somatic reversion suggests revertant stem cell clones are under positive selection and/or rate of mitotic recombination is elevated PMID: 20798280
    16. Data show that TIMP-1 and cytokeratin-10 were identified as 2 newly synthesized secreted proteins in PMID: 19904223
    17. Expression was altered in oral lichen planus lesions PMID: 19776502
    18. Mutations in codon 156 of K10, i.e. R156S, R156P, R156H were found in epidermolytic hyperkeratosis. PMID: 12234709
    19. cytokeratin 10 molecules were shown to be exposed on the surface of both desquamated nasal epithelial cells and keratinocytes; Staphylococcus aureus clumping factor B (ClfB) was shown to bind to cytokeratin K10 from the desquamated nasal epithelial cells PMID: 12427098
    20. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha is observed in transgenic mice expressing keratin K10 in the basal layer of the epidermis. PMID: 12566451
    21. normal cornified cell envelope is formed during the process of human epidermal keratinization, even if the suprabasal keratin filament network is disrupted as with this particular K10 mutation, M150T in BCIE PMID: 14705805
    22. cytokeratin 10 may have a role in progression of head and neck squamous cell carcinoma. PMID: 15254692
    23. We demonstrate that a recessive mutation in KRT10 leading to a complete human K10 knockout can cause EHK PMID: 16505000
    24. Candidate autoantigen in chronic, antibiotic-resistant Lyme arthritis. PMID: 16888010
    25. Squamous cell carcinoma (SCC) in mature cystic teratoma (MCT) expressed CK10 less frequently, but CK18 more frequently. SCC in MCT may be derived from metaplastic squamous epithelium. PMID: 17542994
    26. Mild recessive bullous congenital ichthyosiform erythroderma due to a previously unidentified homozygous keratin 10 nonsense mutation. PMID: 18219278
    27. siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and K10 mRNAs PMID: 18259765
    28. CK10 alone, or in combination with CK19, can be a novel predictor for poor prognosis of hepatocellular carcinoma patients after curative resection. PMID: 18559605
    29. EHK is an autosomal dominant disorder of keratinization, caused by mutations in either the KRT1 or KRT10 genes. Our patient presents EHK with palmoplantar involvement and KRT10 mutation. PMID: 19443303
    30. premature termination codon of KRT10 maybe involved in recessive epidermolytic hyperkeratosis PMID: 19474805
    31. Infection by HPV may alter the differentiation status of the epidermis, leading to delayed or absent expression of cytokeratin 10. PMID: 19515043

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  • 相關(guān)疾病：
    Epidermolytic hyperkeratosis (EHK); Ichthyosis annular epidermolytic (AEI); Erythroderma, ichthyosiform, congenital reticular (CRIE)
  • 亞細(xì)胞定位：
    Secreted, extracellular space. Cell surface.
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6413

    OMIM: 113800

    KEGG: hsa:3858

    STRING: 9606.ENSP00000269576

    UniGene: Hs.99936