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LDHC Recombinant Monoclonal Antibody

  • 中文名稱：
    LDHC重組抗體
  • 貨號(hào)：
    CSB-RA886298A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing Hela cells stained with CSB-RA886298A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA886298A0HU LDHC重組單克隆抗體是針對(duì)乳酸脫氫酶C亞基（LDHC）開(kāi)發(fā)的高特異性科研試劑。該抗體通過(guò)重組蛋白免疫策略制備，經(jīng)ELISA和流式細(xì)胞術(shù)（FC）嚴(yán)格驗(yàn)證，在FC應(yīng)用中推薦使用1:50-1:200稀釋比例。LDHC作為糖酵解關(guān)鍵酶，特異性地表達(dá)于生殖細(xì)胞及多種腫瘤組織，其異常表達(dá)與精子活力調(diào)控及腫瘤代謝重編程密切相關(guān)。本產(chǎn)品能特異性識(shí)別天然構(gòu)象的LDHC蛋白，在FC檢測(cè)中展現(xiàn)出優(yōu)異的信號(hào)分辨率和低背景特性，適用于活細(xì)胞表面標(biāo)記及胞內(nèi)蛋白定位分析。該抗體具有高批次穩(wěn)定性，可為生殖生物學(xué)研究（如精子功能評(píng)估）、腫瘤微環(huán)境代謝研究（包括腫瘤細(xì)胞能量代謝通路解析）以及生殖系統(tǒng)相關(guān)疾病機(jī)制探索提供可靠工具。其優(yōu)化的FC性能特別適合用于流式細(xì)胞術(shù)檢測(cè)中低豐度靶標(biāo)的精準(zhǔn)識(shí)別，為科研人員開(kāi)展細(xì)胞水平的功能研究提供有效支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X), LDHC, LDH3 LDHX
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human LDHC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    9F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Possible role in sperm motility.
  • 基因功能參考文獻(xiàn)：
    1. Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma. PMID: 28351304
    2. three uniquely identified proteins (CDK6 , galectin-3-binding protein and LDH C) were found, which show tight connection with prostate cancer and presence of all of them was previously linked to certain aspects of prostate cancer PMID: 26503549
    3. Down-regulated LDH-C4 expression is significantly correlated with lowered enzyme activity in human spermatozoa. PMID: 25795631
    4. This is the first report to show a positive correlation between LDH-3 and hemolytic parameters in sickle cell anemia. PMID: 26069337
    5. LDH3 was increased in essential thrombocythemia. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
    6. LDH3 is a supporting diagnostic marker in cases of chronic tuberculosis. PMID: 17935709
    7. hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation PMID: 18930904

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    LDH/MDH superfamily, LDH family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6544

    OMIM: 150150

    KEGG: hsa:3948

    STRING: 9606.ENSP00000280704

    UniGene: Hs.654377