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  4. LY6E Recombinant Monoclonal Antibody

LY6E Recombinant Monoclonal Antibody

  • 中文名稱：
    LY6E Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA619076MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of A549 cell with CSB-RA619076MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
    • The Binding Activity of Human LY6E with Anti-LY6E recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LY6E protein (CSB-MP619076HU) at 2 μg/mL can bind Anti-LY6E recombinant antibody. The EC50 is 2.483-3.282 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA619076MA1HU LY6E重組單克隆抗體是專為科研實驗設(shè)計的高特異性檢測工具，靶向淋巴細胞抗原6復(fù)合物E（LY6E）蛋白。該蛋白作為干擾素刺激基因產(chǎn)物，在固有免疫應(yīng)答中發(fā)揮重要作用，尤其參與調(diào)控病毒入侵及宿主防御機制。本產(chǎn)品經(jīng)ELISA及免疫熒光（IF）技術(shù)嚴格驗證，在IF實驗中呈現(xiàn)優(yōu)異性能，推薦使用稀釋比為1:50至1:200時可實現(xiàn)清晰的靶蛋白定位與低背景信號，適用于細胞或組織樣本中LY6E的亞細胞分布研究。其在病毒感染模型、宿主-病原體互作機制探索、免疫調(diào)節(jié)通路分析等基礎(chǔ)研究領(lǐng)域具有廣泛應(yīng)用價值，可為病毒受體功能研究、抗病毒蛋白網(wǎng)絡(luò)解析等實驗提供可靠支持。該重組單克隆抗體具有高親和力與批次間一致性，能夠滿足蛋白質(zhì)相互作用分析、免疫熒光共定位等精細化實驗需求，為長期科研項目提供穩(wěn)定的檢測保障。
  • Uniprot No.：
  • 基因名：
  • 別名：
    LY6E antibody; 9804 antibody; RIGE antibody; SCA2 antibody; TSA1 antibody; Lymphocyte antigen 6E antibody; Ly-6E antibody; Retinoic acid-induced gene E protein antibody; RIG-E antibody; Stem cell antigen 2 antibody; SCA-2 antibody; Thymic shared antigen 1 antibody; TSA-1 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LY6E protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    mIgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    29C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.; (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus. In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E. Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape.
  • 基因功能參考文獻：
    1. LY6E belongs to a growing class of interferon-inducible factors that broadly enhance viral infectivity in an interferon-independent manner. PMID: 30190477
    2. LY6E knockdown by targeted-siRNA inhibited gastric cancer cell survival and proliferation and induced G1-S cell cycle arrest and apoptosis in gastric cancer cells PMID: 29448250
    3. High LY6E expression is associated with breast cancer. PMID: 27589564
    4. LY6E overexpression is associated with Breast Cancer Progression, Immune Escape, and Drug Resistance. PMID: 27197181
    5. LY6E is a positive modulator of HIV-1 infection in primary human peripheral blood mononuclear cells, immortalized CD4+ T lymphoid cells, and macrophages. HIV Long Terminal Repeat-driven HIV-1 gene expression is also enhanced by LY6E, suggesting additional roles of LY6E in HIV-1 replication. PMID: 28130445
    6. LY6E level of gene expression may serve as good biomarkers for systemic lupus erythematosus diagnosis. PMID: 25344775
    7. the LY6E pathway in monocytes represents one of negative feedback mechanisms that counterbalance monocyte activation which may serve as a potential target for immune intervention. PMID: 25225669
    8. This study suggested that a mutation in SCA2 or SCA3/MJD may be one of the genetic causes of Parkinson's disease in china. PMID: 19672991
    9. Increased expression of the type I interferon-inducible gene, lymphocyte antigen 6 complex locus E, in peripheral blood cells is predictive of lupus activity in a large cohort of Chinese lupus patients. PMID: 18755862
    10. Two SCA3 and one SCA2 cases have been identified which show autosomal dominant inheritance in Parkinson disease. PMID: 18990604

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性：
    Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6727

    OMIM: 601384

    KEGG: hsa:4061

    STRING: 9606.ENSP00000292494

    UniGene: Hs.521903