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  4. MMAE&MMAF Recombinant Monoclonal Antibody

MMAE&MMAF Recombinant Monoclonal Antibody

  • 中文名稱：
    MMAE&MMAF重組抗體
  • 貨號：
    CSB-RA903890I1m
  • 規(guī)格：
    ￥3000
  • 圖片：
    • The Binding Activity of Disitamab vedotin (Synonyms: RC48) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.523 to 5.356 ng/mL.
    • The Binding Activity of Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.022 to 4.198 ng/mL.
    • The Binding Activity of Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 3.523 to 5.356 ng/mL and 3.022 to 4.198 ng/mL, respectively.
    • The purity of MMAE&MMAF was greater than 95% as determined by SEC-HPLC
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MMAE&MMAF重組單克隆抗體是針對抗體藥物偶聯(lián)物（ADC）中關(guān)鍵細(xì)胞毒性成分開發(fā)的檢測工具，適用于酶聯(lián)免疫吸附實驗（ELISA）平臺。該抗體特異性識別單甲基奧瑞他汀E（MMAE）和單甲基奧瑞他汀F（MMAF）兩種微管聚合抑制劑，這兩種小分子化合物通過破壞微管網(wǎng)絡(luò)抑制細(xì)胞分裂，廣泛應(yīng)用于靶向抗癌藥物的開發(fā)。經(jīng)嚴(yán)格驗證，該抗體在1:5000至1:50000的寬泛稀釋范圍內(nèi)保持穩(wěn)定檢測性能，具備高靈敏度和低交叉反應(yīng)特性，可精準(zhǔn)檢測復(fù)雜生物樣本中MMAE/MMAF的微量存在。其應(yīng)用場景涵蓋ADC藥物的體外效價評估、藥物偶聯(lián)效率分析以及藥代動力學(xué)研究等領(lǐng)域，為科研人員提供可靠的定量檢測方案，特別適用于藥物開發(fā)過程中關(guān)鍵質(zhì)量屬性的監(jiān)控及作用機制研究，是生物制藥領(lǐng)域基礎(chǔ)研究的重要工具。
  • 基因名：
    MMAE; MMAF
  • 別名：
    MMAE, Monomethyl auristatin E, SGD-1010, Vedotin; MMAF, Monomethylauristatin F
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    MMAE-BSA
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25G12B5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價