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MRAS Recombinant Monoclonal Antibody

  • 中文名稱：
    MRAS重組抗體
  • 貨號：
    CSB-RA158563A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
      All lanes: MRAS antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 24, 16 kDa
      Observed band size: 24 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MRAS Recombinant Monoclonal Antibody（CSB-RA158563A0HU）是針對MRAS蛋白開發(fā)的高特異性抗體，靶向RAS家族中參與細胞信號轉(zhuǎn)導(dǎo)調(diào)控的關(guān)鍵成員MRAS。該蛋白通過介導(dǎo)RAS/MAPK信號通路調(diào)控細胞增殖、分化與存活，其異常表達與多種腫瘤發(fā)生及轉(zhuǎn)移密切相關(guān)。本抗體采用重組表達技術(shù)制備，經(jīng)嚴格驗證可在Western Blot（WB）實驗中穩(wěn)定識別天然及重組MRAS蛋白，推薦使用稀釋比為1:500-1:2000，實驗結(jié)果顯示特異性結(jié)合且背景干擾低，同時適用于ELISA平臺對目標(biāo)蛋白的定量檢測。該產(chǎn)品為科研領(lǐng)域提供可靠工具，可應(yīng)用于腫瘤發(fā)生機制研究、MAPK信號通路調(diào)控分析、體外細胞模型功能驗證等場景，尤其適用于探索MRAS在癌癥生物學(xué)中的功能及其與其他RAS家族蛋白的相互作用研究，為靶向治療開發(fā)提供基礎(chǔ)實驗支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Ras-related protein M-Ras (Ras-related protein R-Ras3), MRAS, RRAS3
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human MRAS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18E11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
  • 基因功能參考文獻：
    1. acute coronary syndrome in Czechs (30.4% vs 29.4% carriers of the minor T allele of MRAS[recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females) PMID: 29264877
    2. Results discovered for the first time that MRAS is recurrently mutated, indicating that MRAS mutations could drive tumorigenesis of Type IV gastric neoplasm. PMID: 27891760
    3. The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. PMID: 25973078
    4. The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population. PMID: 25800439
    5. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
    6. implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf PMID: 12138204
    7. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. PMID: 17538012
    8. Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43. PMID: 19198612

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 組織特異性：
    Expression highly restricted to the brain and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7227

    OMIM: 608435

    KEGG: hsa:22808

    STRING: 9606.ENSP00000289104

    UniGene: Hs.527021