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MRAS Recombinant Monoclonal Antibody

  • 中文名稱：
    MRAS重組抗體
  • 貨號：
    CSB-RA014781MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA014781MA1HU diluted at 1:600 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of Hela cell with CSB-RA014781MA1HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA014781MA1HU MRAS重組單克隆抗體是針對MRAS靶點研發(fā)的高特異性科研試劑，經(jīng)ELISA、免疫組化（IHC）和免疫熒光（IF）等多平臺嚴(yán)格驗證，在IHC應(yīng)用中推薦1:20-1:200稀釋度，IF實驗建議1:20-1:200稀釋比例。該抗體通過抗原親和力純化工藝制備，展現(xiàn)出優(yōu)異的靶標(biāo)結(jié)合特異性，在多種組織樣本中均能實現(xiàn)清晰的細(xì)胞膜/細(xì)胞質(zhì)定位信號，且背景干擾低，重復(fù)性穩(wěn)定。MRAS作為RAS癌基因家族成員，參與調(diào)控MAPK信號通路，在細(xì)胞增殖、分化及腫瘤發(fā)生發(fā)展中具有重要作用。本產(chǎn)品適用于探究MRAS在腫瘤微環(huán)境中的表達(dá)模式、癌癥相關(guān)信號通路調(diào)控機(jī)制以及細(xì)胞功能研究，可配合病理學(xué)分析、分子互作實驗及細(xì)胞模型構(gòu)建，為腫瘤生物學(xué)基礎(chǔ)研究提供精準(zhǔn)的實驗工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ42964 antibody; M ras antibody; M-ras antibody; Mras antibody; Muscle and microspikes Ras antibody; Muscle RAS oncogene homolog antibody; Muscle Ras oncogene homologue antibody; Muscle Ras viral oncogene homolog antibody; R ras3 antibody; R-ras3 antibody; Ras related protein MRas antibody; Ras related protein RRas3 antibody; Ras-related protein M-Ras antibody; Ras-related protein R-Ras3 antibody; RASM_HUMAN antibody; Related Ras viral oncogene homolog 3 antibody; RRas3 antibody; XRas antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MRAS protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
  • 基因功能參考文獻(xiàn)：
    1. acute coronary syndrome in Czechs (30.4% vs 29.4% carriers of the minor T allele of MRAS[recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females) PMID: 29264877
    2. Results discovered for the first time that MRAS is recurrently mutated, indicating that MRAS mutations could drive tumorigenesis of Type IV gastric neoplasm. PMID: 27891760
    3. The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. PMID: 25973078
    4. The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population. PMID: 25800439
    5. Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
    6. implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf PMID: 12138204
    7. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. PMID: 17538012
    8. Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43. PMID: 19198612

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 組織特異性：
    Expression highly restricted to the brain and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7227

    OMIM: 608435

    KEGG: hsa:22808

    STRING: 9606.ENSP00000289104

    UniGene: Hs.527021