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  4. MYL9 Recombinant Monoclonal Antibody

MYL9 Recombinant Monoclonal Antibody

  • 中文名稱：
    MYL9重組抗體
  • 貨號：
    CSB-RA015318MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human MYL9 with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL9 (CSB-YP015318HU) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 4.628-6.430 ng/mL.
    • The Binding Activity of Human MYL12B with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12B (CSB-EP015308HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 7.760-8.646 ng/mL.
    • The Binding Activity of Human MYL12A with Anti-MYL9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MYL12A (CSB-EP015307HUc7) at 2 μg/mL can bind Anti-MYL9 recombinant antibody, the EC50 is 5.325-6.456 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA015318MA1HU是靶向MYL9蛋白的重組單克隆抗體，專為科研實驗設(shè)計。MYL9（肌球蛋白調(diào)節(jié)輕鏈9）是肌球蛋白輕鏈家族成員，在細胞收縮、遷移及細胞形態(tài)維持中發(fā)揮關(guān)鍵作用，尤其參與調(diào)控平滑肌和非肌肉細胞的收縮過程。本產(chǎn)品通過重組表達技術(shù)制備，經(jīng)ELISA平臺嚴格驗證，展現(xiàn)出優(yōu)異的抗原結(jié)合能力，具備高特異性與批次間穩(wěn)定性，可滿足精準(zhǔn)檢測需求。適用于探索細胞骨架動力學(xué)、血管張力調(diào)節(jié)、組織纖維化機制等基礎(chǔ)研究領(lǐng)域，特別在心血管功能調(diào)控、細胞運動相關(guān)疾病模型的分子機制研究中具有應(yīng)用價值，為深入解析細胞收縮信號通路提供可靠工具。該抗體不適用于臨床診斷及治療相關(guān)研究。
  • Uniprot No.：
  • 基因名：
  • 別名：
    MYL9 Recombinant Monoclonal Antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MYL9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG2
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6G11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
  • 基因功能參考文獻：
    1. MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
    2. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
    3. These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
    4. the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
    5. Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
    6. Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
    7. surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
    8. The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
    9. Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
    10. use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 組織特異性：
    Smooth muscle tissues and in some, but not all, nonmuscle cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15754

    OMIM: 609905

    KEGG: hsa:10398

    STRING: 9606.ENSP00000279022

    UniGene: Hs.504687