搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. NFIB Recombinant Monoclonal Antibody

NFIB Recombinant Monoclonal Antibody

  • 中文名稱：
    NFIB Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA942870A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing Hela cells stained with CSB-RA942870A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    NFIB
  • 別名：
    CCAAT Box Binding Transcription Factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; HMGIC/NFIB antibody; NF-I/B antibody; NF1-B antibody; NF1B antibody; NF1B2 antibody; NFI-B antibody; NFI-RED antibody; Nfib antibody; NFIB_HUMAN antibody; NFIB2 antibody; NFIB3 antibody; Nuclear factor 1 B-type antibody; Nuclear factor 1/B antibody; Nuclear Factor 1B antibody; Nuclear Factor I B antibody; Nuclear factor I/B antibody; TGGCA Binding Protein antibody; TGGCA-binding protein antibody; TRANSCRIPTION FACTOR NFIB antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human NFIB
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4E7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能參考文獻：
    1. High NF1B expression is associated with cell growth, aggressiveness, metastasis in gastric cancer. PMID: 30015981
    2. Studied role of miR-30d in tumor invasiveness and migration in non-small lung cancer (NSCLC). Found miR-30d suppressed cell migration and invasion by directly targeting nuclear factor I B (NFIB) in NSCLC. PMID: 28861760
    3. Study highlighted the paradoxical involvement of NFIB in both the inhibition and promotion of tumor development as well as progression in different malignancies; especially between different tumor subtypes within a single organ system, such as in lung, brain and skin,which corroborates its diverse and distinct roles in specific tissues and cell types. [review] PMID: 28596133
    4. we report that the transcription factor NFIB is associated with significantly improved survival in glioblastoma PMID: 27083054
    5. High NFIB levels are associated with expansive growth of a poorly differentiated and almost exclusively E-cadherin (CDH1)-negative invasive tumor cell population. PMID: 27373156
    6. low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients PMID: 27357447
    7. Data indicate that NFIB protein increases EZH2 protein expression downstream of BRN2 protein, which further decreases MITF protein levels. PMID: 28119061
    8. In benign prostatic hyperplasia, luminal NFIB loss correlated with more severe disease. in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA1 binding sites. PMID: 26677878
    9. These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. PMID: 26084801
    10. Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR-365 in cutaneous squamous cell carcinoma development PMID: 24949940
    11. multivariate analysis co-overexpression of NFIB, RANK and RANKL significantly increased the risk of metastasis with an odds ratio of 13.59 PMID: 25764026
    12. Increased expression of NF1B is associated with pilocytic astrocytoma. PMID: 23161775
    13. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity. PMID: 22180456
    14. Tissue microarray results from invasive breast cancer patients, and the immunohistochemistry results showed a significant association between NFIB expression and nuclear grade, estrogen receptor, and HER2 expression status. PMID: 21925980
    15. study revealed that miRNA (miRs-372/373) can promote HBV expression through a pathway involving the transcription factor PMID: 21608007
    16. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation PMID: 21764851
    17. these results suggest that NFIB is a novel and specific biomarker for oxaliplatin resistance in human cancers PMID: 21087353
    18. The the MYB-NFIB fusion characterizes a subset of ACCs and contributes to MYB overexpression. PMID: 20702610
    19. expression of NFI-B2 impairs CD4 transcription on CDd4-positive primary T-lymphocytes and cell lines in HIV-1 infection PMID: 12639247
    20. C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in tumor cells PMID: 17511965
    21. the rearrangement of NFIB might be associated with deep-seated lipomas, such as retroperitoneal or gastro-intestinal lipomas PMID: 18663748
    22. Knockdown of NFIB and NFIC expression using siRNA decreased and increased IGFBP5 expression, respectively. PMID: 18809517
    23. lipomas containing NFIB rearrangements may be related to peculiar clinicohistologic features, including large size, deep situation, infiltration of surrounding muscles, or precocious occurrence. PMID: 19837271

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 數(shù)據庫鏈接：

    HGNC: 7785

    OMIM: 600728

    KEGG: hsa:4781

    STRING: 9606.ENSP00000370340

    UniGene: Hs.644095