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  4. PLEKHA1 Recombinant Monoclonal Antibody

PLEKHA1 Recombinant Monoclonal Antibody

  • 中文名稱：
    PLEKHA1重組抗體
  • 貨號：
    CSB-RA918477A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate
      All lanes: PLEKHA1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 39 kDa
      Observed band size: 36-55 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA918477A0HU PLEKHA1重組單克隆抗體是針對人源PLEKHA1蛋白開發(fā)的高特異性檢測工具。該抗體靶向的PLEKHA1（Pleckstrin Homology Domain Containing A1）是一種參與細胞間連接調(diào)控的關(guān)鍵分子，通過其PH結(jié)構(gòu)域參與細胞極性維持和信號轉(zhuǎn)導(dǎo)過程，在維持上皮組織屏障功能及腫瘤微環(huán)境調(diào)控中發(fā)揮重要作用。經(jīng)嚴格驗證，本抗體在Western Blot實驗中可識別特異性條帶，推薦工作濃度為1:500-1:2000，同時在ELISA平臺中表現(xiàn)出良好的抗原結(jié)合能力。適用于研究細胞連接復(fù)合體動態(tài)變化、上皮-間質(zhì)轉(zhuǎn)化機制以及腫瘤細胞遷移等方向，特別推薦用于細胞裂解液或組織樣本中PLEKHA1蛋白表達的定量及定性分析。該產(chǎn)品經(jīng)過重組表達技術(shù)制備，具有批次間一致性高的特點，可為細胞生物學及腫瘤微環(huán)境相關(guān)研究提供穩(wěn)定可靠的檢測支持。
  • Uniprot No.：
  • 基因名：
    PLEKHA1
  • 別名：
    Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1), PLEKHA1, TAPP1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PLEKHA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    16C9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
  • 基因功能參考文獻：
    1. investigated the association of PLEKHA1 958A/G, polymorphisms with Age-Related Macular Degeneration (AMD) risk. PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014) PMID: 29565837
    2. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
    3. CX3CR1 (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population. PMID: 25050486
    4. This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2/HTRA1 to age-related macular degeneration risk. PMID: 24013816
    5. TAPP1 binds to protein tyrosine phosphatase PTPL1. PMID: 14516276
    6. syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation PMID: 15485858
    7. PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility. PMID: 16080115
    8. Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1" risk alleles. PMID: 18079691
    9. Independent of CFH genotype or smoking history, an individual's risk of AMD (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region. PMID: 18164066

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.
  • 組織特異性：
    Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14335

    OMIM: 607772

    KEGG: hsa:59338

    STRING: 9606.ENSP00000357986

    UniGene: Hs.643512