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中文名稱:PRLR Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA018727MA1HU
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規(guī)格:¥1320
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圖片:
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IHC image of CSB-RA018727MA1HU diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:CSB-RA018727MA1HU PRLR重組單克隆抗體是針對(duì)催乳素受體(Prolactin Receptor)研發(fā)的高特異性科研工具。該抗體靶向的PRLR屬于I型細(xì)胞因子受體超家族成員,在介導(dǎo)催乳素信號(hào)傳導(dǎo)中發(fā)揮關(guān)鍵作用,參與調(diào)控乳腺發(fā)育、泌乳功能及生殖系統(tǒng)生理活動(dòng)。經(jīng)嚴(yán)格驗(yàn)證,本品在ELISA實(shí)驗(yàn)中可精準(zhǔn)識(shí)別重組或天然PRLR蛋白,同時(shí)在免疫組化(IHC)應(yīng)用中能清晰顯示組織樣本中PRLR的分布特征,推薦使用稀釋比例為1:50至1:200。適用于體外培養(yǎng)細(xì)胞或動(dòng)物組織切片中PRLR表達(dá)水平的定性及定位分析,為研究乳腺生物學(xué)、生殖內(nèi)分泌調(diào)控以及相關(guān)疾病模型(如乳腺增生或激素依賴性腫瘤機(jī)制)提供可靠的檢測(cè)支持。其優(yōu)異的批間穩(wěn)定性和低交叉反應(yīng)性保障了實(shí)驗(yàn)結(jié)果的重復(fù)性與準(zhǔn)確性,是基礎(chǔ)科研領(lǐng)域探索PRLR信號(hào)通路及功能研究的理想選擇。
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Uniprot No.:
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基因名:
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別名:AI987712 antibody; CLONE SPM213 antibody; CPRLP antibody; Delta 4-delta 7/11 truncated prolactin receptor antibody; Delta 4-SF1b truncated prolactin receptor antibody; HPRL antibody; hPRL receptor antibody; hPRLrI antibody; Lactogen receptor antibody; MFAB antibody; MGC105486 antibody; OPR antibody; OTTHUMP00000115998 antibody; Pr-1 antibody; Pr-3 antibody; PRL R antibody; PRL-R antibody; PRLR antibody; Prlr-rs1 antibody; PRLR_HUMAN antibody; Prolactin receptor a antibody; Prolactin receptor antibody; Prolactin receptor delta 7/11 antibody; RATPRLR antibody; Secreted prolactin binding protein antibody; Truncated testis-specific box 1-C prolactin receptor antibody; wu:fj65c07 antibody; rolinsatamab
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反應(yīng)種屬:Human
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免疫原:Recombinant Human PRLR protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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抗體亞型:hIgG1
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純化方式:Affinity-chromatography
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克隆號(hào):13G8
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA, IHC
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推薦稀釋比:
Application Recommended Dilution IHC 1:50-1:200 -
Protocols:
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儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
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基因功能參考文獻(xiàn):
- In a replication study of the association between the prolactin receptor gene intron C/T polymorphism (rs37389) and recurrent miscarriage, no association was found. PMID: 28980840
- Low PRLR expression is associated with Triple Negative Breast Cancer. PMID: 27480353
- These results illustrate promising antitumor activity against PRLR-positive breast cancer xenografts and support the evaluation of anti-PRLR antibody-drug conjugate as potential therapeutic agents in breast cancer. PMID: 28377489
- Prl receptor is expressed at different levels in the majority of glioblastoma multiforme tumors. Prolactin stimulation resulted in increased STAT5 phosphorylation and increased cellular invasion. PMID: 27788487
- PRLRI146L and PRLRI176V variants are not associated with breast cancer or multiple breast fibroadenomas risk. PMID: 27575941
- This study identified 4 PRLR variations (p.Ile76Val, p.Ile146Leu, p.Glu108Lys and p.Glu554Gln) in 16 Sporadic Prolactinoma in Humans. PMID: 26641246
- results highlight PRLR as an independent predictor of favorable prognosis in human breast cancer PMID: 26317306
- Two markers for the PRL peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped. PMID: 26513615
- The prolactin receptor is constitutively expressed on regulatory T and effector T cells in systemic lupus erythematosus patients, and this expression is higher than in healthy individuals. PMID: 26844452
- There is a possible role for PRLR in the progression of cervical cancer. PMID: 24990775
- Study shows that position 146 plays a central role in directing intrinsic properties of the PRLR, including extracellular domain folding, PRL-responsiveness, and ligand-independent activity of the receptor. PMID: 25524456
- Data suggest that (1) cell membrane/lipid bilayer binding of PRLR and (2) tyrosine phosphorylation of PRLR intracellular domain are independent. PMID: 25846210
- long PRLR plays an important role in breast cancer metastasis. PMID: 26095602
- a residue quartet in the extracellular membrane proximal domain of the homodimeric cytokine receptor prolactin receptor is a key regulator of intracellular signaling discrimination PMID: 25784554
- PRL induced transient signaling pathways in neurons and modulated ion channels. [review] PMID: 24758841
- exposure to prolactin increases TNF-alpha release from CD14(+) monocytes of rheumatoid arthritis patients, which can be abolished by PRLR gene silencing or treating with MAPK inhibitor. PMID: 24997655
- High MFAB expression is associated with testicular germ cell tumor and glioblastomas. PMID: 24391856
- Negative/low expression is associated with poorly differentiated and larger breast tumors in Poland PMID: 24249584
- Major changes in prolactin receptor conformation and dimerization affinity are triggered by single mutations in critical regions of D1. PMID: 24735798
- PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria. PMID: 24333596
- Hypertrimethylation on H3K27 of the p53 gene promoter region due to elevated expression of DeltaS2 PRLR by alternative splicing of the pre-mRNA in its full-length form might serve as a new mechanism underlying prostate cancer PMID: 24032713
- Data suggest that signal transduction via prolactin and prolactin receptor plays role in trophoblast cell migration and invasion; PRLR is expressed by extravillous cytotrophoblasts and first-trimester placental bed tissue. PMID: 23849393
- PRL-induced transient signaling in sensory neurons is governed by PI3K or PKCepsilon, mediated via the PRLR-S isoform, and transient effects mediated by PRLR-S are inhibited by presence of PRLR-L in these cells. PMID: 24142695
- SNPs of the PRLR gene 5' UTR and promoter region are associated with increased risk for gestational diabetes in a population of Chilean subjects. PMID: 23651351
- Thus, the familial hyperprolactinemia appears to be due to a germline, loss-of-function mutation in PRLR, resulting in prolactin insensitivity. PMID: 24195502
- Results demonstrate a novel function for hepatic PRLR in the regulation of insulin sensitivity and provide important insights concerning the nutritional regulation of PRLR expression. PMID: 23775766
- Our data suggest that prolactin receptor presence meaningfully affects growth hormone receptor use in breast cancer cells. PMID: 23192981
- The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer PMID: 23159947
- Our results indicate no significant association of prolactin and PRLR polymorphisms with clozapine response, tardive dyskinesia diagnosis or its severity in patients with schizophrenia PMID: 21305610
- can be activated by three sequence-diverse human hormones: prolactin, GH, and placental lactogen [review] PMID: 22577091
- PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours PMID: 22606260
- The structure of the human prolactin receptor reveals a structural link between the WSXWS motif, hormone binding, and receptor dimerization and we propose it as a general mechanism for class 1 receptor activation. PMID: 22325776
- PRL signaling through the long form prolactin receptor causes reduced fatty acid oxidation, increased lipid storage, glucose intolerance, and obesity. PMID: 21989556
- data provide limited support for an association between common variations in PRLR and breast cancer risk PMID: 21470416
- The association of the PRLr with HMGN2 enables Stat5a-responsive promoter binding, thus facilitating transcriptional activation and promoting anchorage-independent growth. PMID: 21816901
- Our study suggests the prolactin receptor gene is a molecular target that may be important in the pathogenesis and progression of lobular neoplasia PMID: 20658264
- Enhanced complex formation of ERalpha dimer with SP1 and C/EBPbeta by E2 has an essential role in the transcriptional activation of the hPRLR gene. PMID: 21670145
- Data show that cells expressing higher long:short PRLR ratios had increased growth, survival and migration in response to PRL and suggest that PRLR antagonists may be therapeutically beneficial in ovarian cancer. PMID: 21775057
- Endogenous GH receptor(GHR) and PRLR associate, possibly as a GHR-PRLR heterodimer, in human breast cancer cells and GH signaling in these cells is largely mediated by the PRLR in the context of both PRLR-PRLR homodimers and GHR-PRLR heterodimers. PMID: 21310852
- The positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer. PMID: 20335148
- SIRPalpha modulates PRL receptor-associated signaling as a function of integrin occupancy by mediating integrin-PRL receptor cross-talk and contributing to breast cancer biology. PMID: 20826546
- both Zn(2+) and human PRLr binding influence human PRL conformers in an interdependent fashion PMID: 21510945
- Functional impact of manipulation on the relative orientation of human prolactin receptor domains. PMID: 21591677
- Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP transcription factors PMID: 21238538
- Rabbit antibodies have high titer and could specifically recognize each isoform of PRLR in breast cancer cell lines and human breast carcinoma biopsies. PMID: 21144038
- Prolactin receptor signaling contributes to the local inflammatory response within the atherosclerotic plaque and thus to atherogenesis. PMID: 21068074
- Blockade of the PRLR represents a novel treatment for patients with advanced breast or prostate cancer with limited therapeutic options. PMID: 20846877
- acetylation and deacetylation provide the rheostat-like regulation for the cytokine receptor PRLR in its cytoplasmic loop dimerization and subsequent STAT5 activation PMID: 20962278
- This study allowed to visualize for the first time the loop L5 spanning PRLR2 residues Thr133-Phe140, revealing its central implication for the three intermolecular interfaces of the 1:2 complex between natural prolactin and two PRLR chains. PMID: 20875426
- prolactin receptor expression is common in colorectal cancer PMID: 20453834
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相關(guān)疾病:Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.; [Isoform 7]: Secreted.
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蛋白家族:Type I cytokine receptor family, Type 1 subfamily
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組織特異性:Expressed in breast, placenta, kidney, liver and pancreas.
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數(shù)據(jù)庫(kù)鏈接:
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