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SIGLEC9 Recombinant Monoclonal Antibody

  • 中文名稱：
    SIGLEC9 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA021303MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human SIGLEC9 with Anti-SIGLEC9 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SIGLEC9 (CSB-MP021303HU) at 2 μg/mL can bind Anti-SIGLEC9 recombinant antibody. The EC50 is 1.033-1.429 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    SIGLEC9 Recombinant Monoclonal Antibody（CSB-RA021303MA1HU）是一款高特異性抗體，靶向唾液酸結(jié)合免疫球蛋白樣凝集素9（SIGLEC9），該蛋白屬于Siglec家族免疫調(diào)節(jié)受體，主要表達(dá)于髓系細(xì)胞（如巨噬細(xì)胞、中性粒細(xì)胞），通過(guò)識(shí)別唾液酸化配體介導(dǎo)抑制性信號(hào)，參與炎癥調(diào)控、細(xì)胞凋亡及免疫耐受等生物學(xué)過(guò)程。本產(chǎn)品經(jīng)ELISA嚴(yán)格驗(yàn)證，在1:5000至1:50000稀釋范圍內(nèi)表現(xiàn)出優(yōu)異的線性檢測(cè)性能，適用于靶蛋白的體外定量分析與功能性研究。該抗體為科研人員提供可靠工具，可應(yīng)用于免疫微環(huán)境解析、炎癥相關(guān)疾病機(jī)制探索（如膿毒癥、腫瘤免疫逃逸）以及免疫細(xì)胞信號(hào)通路研究等領(lǐng)域，支持包括細(xì)胞培養(yǎng)上清液或重組蛋白樣本的ELISA檢測(cè)，助力于基礎(chǔ)免疫學(xué)及轉(zhuǎn)化醫(yī)學(xué)研究中的靶點(diǎn)功能驗(yàn)證。
  • Uniprot No.：
  • 基因名：
    SIGLEC9
  • 別名：
    CD329 antibody; CDw329 antibody; FOAP 9 antibody; OB binding protein like antibody; OBBP LIKE antibody; Protein FOAP 9 antibody; Protein FOAP-9 antibody; sialic acid binding Ig like lectin 9 antibody; Sialic acid-binding Ig-like lectin 9 antibody; Sialic acid-binding immunoglobulin like lectin 9 antibody; SIGL9_HUMAN antibody; Siglec 9 antibody; Siglec-9 antibody; SIGLEC9 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SIGLEC9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    5H2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
  • 基因功能參考文獻(xiàn)：
    1. The SIGLEC9 rs2075803 G/rs2258983 A haplotype, which corresponds to a Siglec-9 variant that is less effective at suppressing inflammatory response, may be a risk factor for the development of emphysema. PMID: 27878892
    2. Glycophorin A, the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood. PMID: 28416510
    3. Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA). PMID: 28273363
    4. The mechanism of the Siglec-9 and AOC3 interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain. PMID: 27893774
    5. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway that follows engagement of Siglec-9. PMID: 27595232
    6. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages. PMID: 26923638
    7. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa. PMID: 26694037
    8. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways. PMID: 25747723
    9. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung cancer patients PMID: 25225409
    10. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3. PMID: 24882272
    11. Protein degradation of focal adhesion kinase and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells. PMID: 24145038
    12. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway. PMID: 24045940
    13. The Siglec-9 peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer. PMID: 21821708
    14. Siglec-9 A391C was the only polymorphism related to TCR-mediated signaling in human Siglec-9, resulting in less inhibition compared to the wild type. PMID: 20733319
    15. These results suggest that Siglec-9 expressed on DCs is involved in immunoregulation through ligation with mucins in an epithelial cancer patient. PMID: 20971061
    16. MUC16-Siglec-9 binding likely mediates inhibition of anti-tumor immune responses. PMID: 20497550
    17. Septic shock patients exhibit different ex vivo death responses of blood neutrophils after Siglec-9 ligation early in shock. PMID: 19295491
    18. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc. PMID: 14693915
    19. Siglec-9 can inhibit Fc epsilon receptor I-mediated serotonin release from rat basophilic leukemia cells and recruit the tyrosine phosphatases SHP-1 and SHP-2. PMID: 15557178
    20. data suggest that apoptotic (ROS- and caspase-dependent) and nonapoptotic (ROS-dependent) death pathways are initiated in neutrophils via Siglec-9 PMID: 15827126
    21. Siglecs-9 did not interact with sulfate derivatives of LacNAc and sulfated oligosaccharides containing sialic acid. PMID: 16732727
    22. The Siglec-9 provides not only a useful marker for certain subsets of AML, but also a potential therapeutic target. PMID: 16828866
    23. These results demonstrate that Siglec-9 enhances the production of the anti-inflammatory cytokine IL-10 in macrophages. PMID: 18325328
    24. A review of the cytotoxic effects of natural anti-Siglec9 autoantibodies on both neutrophils and eosinophils. PMID: 18558361
    25. Increased bacterial survival are also facilitated by group b Streptococcus sialylated capsular polysaccharide interactions with Siglec-9. PMID: 19196661
    26. Data suggest that age-specific interactions between Siglec-9 and SHP-1 may influence the altered inflammatory responsiveness and longevity of neonatal polymorphonuclear neutrophils. PMID: 19542910

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adre
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10878

    OMIM: 605640

    KEGG: hsa:27180

    STRING: 9606.ENSP00000413861

    UniGene: Hs.245828