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SLC27A4 Recombinant Monoclonal Antibody

  • 中文名稱：
    SLC27A4重組抗體
  • 貨號(hào)：
    CSB-RA235828A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Mouse brain tissue
      All lanes: SLC27A4 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 73, 27 kDa
      Observed band size: 42 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA235828A0HU SLC27A4重組單克隆抗體是針對(duì)溶質(zhì)載體家族27成員4（SLC27A4/FATP4）設(shè)計(jì)的高特異性科研試劑。SLC27A4作為脂肪酸轉(zhuǎn)運(yùn)蛋白家族成員，在長(zhǎng)鏈脂肪酸的跨膜轉(zhuǎn)運(yùn)、脂質(zhì)代謝調(diào)控及能量穩(wěn)態(tài)維持中發(fā)揮關(guān)鍵作用，其表達(dá)異常與代謝紊亂、皮膚屏障功能障礙等研究領(lǐng)域密切相關(guān)。該抗體經(jīng)多種實(shí)驗(yàn)驗(yàn)證，適用于ELISA和Western Blot技術(shù)平臺(tái)，在WB實(shí)驗(yàn)中推薦使用1:500-1:2000稀釋范圍，能夠特異性識(shí)別目標(biāo)蛋白，且在不同物種來(lái)源的樣本中均表現(xiàn)出低背景和高信噪比特性。該產(chǎn)品可廣泛應(yīng)用于細(xì)胞或組織中SLC27A4蛋白的定量檢測(cè)、脂肪酸代謝相關(guān)信號(hào)通路研究、肥胖或糖尿病等代謝疾病模型的分子機(jī)制解析，以及藥物靶點(diǎn)篩選中的功能驗(yàn)證實(shí)驗(yàn)，為脂質(zhì)代謝、細(xì)胞生物學(xué)及營(yíng)養(yǎng)生理學(xué)等基礎(chǔ)研究提供可靠工具。本產(chǎn)品僅限科學(xué)研究用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4), SLC27A4, ACSVL4 FATP4
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from human SLC27A4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    11A1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.
  • 基因功能參考文獻(xiàn)：
    1. SLC27A4 gene mutation is responsible in the diagnosis of ichthyosis prematurity syndrome in a premature infant. PMID: 26341232
    2. expand the mutational repertory of FATP4 with three undescribed pathogenic mutations in two families PMID: 27168232
    3. The results have interesting implications that SLC27A4/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application. PMID: 26662804
    4. no association between placental expression and maternal body mass index PMID: 27016784
    5. we resequenced the SLC27A3 and SLC27A4 genes using 267 autism spectrum disorders(ASD) patient and 1140 control samples and detected 47 and 30 variants for the SLC27A3 and SLC27A4, revealing that they are highly polymorphic with multiple rare variants. PMID: 26548558
    6. We describe two siblings with ichthyosis prematurity syndrome and report a recurrent homozygous mutation (c.1430T>A) that is predicted to lead to a p.Val477Asp substitution in fatty acid transport protein 4. PMID: 24889544
    7. the cell surface protein CD36/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA synthetases FATP4 and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping PMID: 24503477
    8. the clinical implications of defects in these transporters and relevant animal models, including the FATP4 animal models and ichthyosis prematurity syndrome, a congenital ichthyosis caused by FATP4 deficiency. [review] PMID: 24120574
    9. FATP4, ichthyin and TGM1 interact in lipid processing essential for maintaining the epidermal barrier function PMID: 23290633
    10. FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum PMID: 23271751
    11. FATP1 and FATP4 proteins perform different functional roles in handling long chain fatty acids in skeletal muscle PMID: 22235293
    12. even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID: 22028793
    13. Mutation in FATP4 in a patient with self-healing congenital verruciform hyperkeratosis.( PMID: 20815031
    14. findings propose fatty acid transport protein 4 as a candidate gene for the insulin resistance syndrome PMID: 14715877
    15. intra-pair correlations revealed that FATP4 expression was significantly up-regulated in acquired obesity." PMID: 15168018
    16. Data suggest that endogenous FATP4 does not function to translocate fatty acids across the plasma membrane, but functions more as a very long-chain acyl-CoA synthetase. PMID: 17901542
    17. Mutations in FATP4 gene cause the ichthyosis prematurity syndrome. PMID: 19631310

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  • 相關(guān)疾病：
    Ichthyosis prematurity syndrome (IPS)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ATP-dependent AMP-binding enzyme family
  • 組織特異性：
    Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tiss
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10998

    OMIM: 604194

    KEGG: hsa:10999

    STRING: 9606.ENSP00000300456

    UniGene: Hs.656699