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  4. TAB1 Recombinant Monoclonal Antibody

TAB1 Recombinant Monoclonal Antibody

  • 中文名稱：
    TAB1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA243394A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA243394A0HU diluted at 1:100 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing jurkat cells stained with CSB-RA243394A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2310012M03Rik antibody; 3'-Tab1 antibody; MAP3K7IP 1 antibody; MAP3K7IP1 antibody; MGC57664 antibody; Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody; TAB 1 antibody; TAB1 antibody; TAB1_HUMAN antibody; TAK1 binding protein 1 antibody; TAK1-binding protein 1 antibody; TGF beta activated kinase 1 binding protein 1 antibody; TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody; TGF-beta-activated kinase 1-binding protein 1 antibody; Transforming growth factor beta activated kinase binding protein 1 antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human TAB1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11B7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
  • 基因功能參考文獻：
    1. High TAB1 expression is associated with colorectal cancer. PMID: 29328486
    2. TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID: 28206956
    3. we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID: 27314954
    4. TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis. PMID: 26884850
    5. miR-29a repressed TAB1-mediated TIMP-1 production in dermal fibroblasts, demonstrating that miR-29a may be a therapeutic target in SSc. PMID: 25549087
    6. Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein. PMID: 25151490
    7. The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. PMID: 24462677
    8. USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID: 23825189
    9. We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation PMID: 22972987
    10. TAK1 plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. PMID: 22525462
    11. data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK activity and subcellular localization and implicate these residues in TAK1- or p38 MAPK-dependent post-transcriptional control of gene expression PMID: 22216226
    12. Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR. PMID: 21159881
    13. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20805296
    14. Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. PMID: 20538596
    15. interaction with p38alpha leads to autophosphorylation and activation of p38alpha PMID: 11847341
    16. The TAK1-TAB1 fusion protein is a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways PMID: 12372426
    17. TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions PMID: 12429732
    18. These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. PMID: 12482967
    19. characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 PMID: 15590691
    20. Determinants that control the specific interactions between TAB1 and MAPK14 are identified. PMID: 16648477
    21. The protein phosphatase 2C alpha fold is conserved in TAB1(a TAK1 regulatory subunit) but some AAs needed for dual metal-binding & catalysis are missing. It is a pseudophosphatase, & may bind/regulate access to phosphorylated AAs on downstream substrates. PMID: 16879102
    22. a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta PMID: 18316610
    23. TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB. PMID: 18456659
    24. periostin is involved in the suppression of cell invasiveness via the TAB1/TAK1 signaling pathway. PMID: 19578758

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  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18157

    OMIM: 602615

    KEGG: hsa:10454

    STRING: 9606.ENSP00000216160

    UniGene: Hs.507681