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  4. VAMP8 Recombinant Monoclonal Antibody

VAMP8 Recombinant Monoclonal Antibody

  • 中文名稱：
    VAMP8 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA843784A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HL-60 whole cell lysate(30μg), MCF-7 whole cell lysate(30μg), SW620 whole cell lysate(30μg), K562 whole cell lysate(30μg), HeLa whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg), Mouse liver tissue lysate(30μg), Mouse kidney tissue lysate(30μg)
      All lanes: VAMP8 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 11 kDa
      Observed band size: 15 kDa
      Exposure time: 2min
    • Overlay Peak curve showing Hela cells stained with CSB-RA843784A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB), VAMP8
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from human VAMP8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2B8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism.
  • 基因功能參考文獻(xiàn)：
    1. our study suggested that VAMP8 gene variants might not contribute to glioma susceptibility and associated with glioma in the Chinese Han population. PMID: 26191281
    2. Vesicle-associated membrane protein 8 as a novel oncogene by promoting cell proliferation and therapeutic resistance in glioma. Targeting VAMP8 may serve as a potential therapeutic regimen for the treatment of glioma. PMID: 25209430
    3. Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. PMID: 25648148
    4. Cytotoxic granule exocytosis is a sequential, multivesicle fusion process requiring VAMP8-mediated recycling endosome fusion before cytotoxic granule fusion. PMID: 26124288
    5. Inhibition of VAMP8, but not VAMP7, significantly reduces viral entry. PMID: 24550300
    6. VAMP8 regulates mucin granule exocytosis in airway goblet cells, and reduction of its expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases PMID: 22144578
    7. Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. PMID: 22192511
    8. The VAMP8 rs1010 polymorphism was associated with CHD risk in Chinese Han population, the A allele might serve as a genetic risk factor of coronary heart disease. PMID: 20533276
    9. Results suggest that the combinational SNARE proteins VAMP8 and Vti1b mediate the fusion of antimicrobial and canonical autophagosomes with lysosomes, an essential event for autophagic degradation. PMID: 20089838
    10. Support a role for VAMP8/endobrevin in the heterogeneity of platelet reactivity, and suggest a role for microRNA-96 in the regulation of VAMP8 expression. PMID: 19943878
    11. VAMP8 is not essential for constitutive exocytosis, although it can be involved in the exocytosis PMID: 19738360
    12. VAMP-3 and VAMP-8 are present in human platelets and are required for granule secretion. PMID: 12130530
    13. Our findings indicate that VAMP5 and VAMP8 are not involved in POAG in the Dutch population. PMID: 16110299
    14. VAMP-8 is unlikely to be a v-SNARE for constitutive exocytosis in HSY cells. PMID: 16195891
    15. Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. PMID: 16690874
    16. Data show that mature human mast cells express a specific pattern of SNARE and that VAMP-7 and VAMP-8, but not VAMP-2, are required for rapid degranulation. PMID: 18253931
    17. A putative association between a VAMP8 gene variant and platelet functions ex vivo, was tested. PMID: 19374688

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  • 亞細(xì)胞定位：
    Lysosome membrane; Single-pass type IV membrane protein. Early endosome membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Zymogen granule membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Synaptobrevin family
  • 組織特異性：
    Platelets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12647

    OMIM: 603177

    KEGG: hsa:8673

    STRING: 9606.ENSP00000263864

    UniGene: Hs.714302